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阿克拉霉素A聚乳酸毫微粒的制备工艺研究
引用本文:何林,蒋学华,李芚. 阿克拉霉素A聚乳酸毫微粒的制备工艺研究[J]. 中国药学杂志, 1998, 33(5): 289-291
作者姓名:何林  蒋学华  李芚
作者单位:华西医科大学药学院
摘    要:
 目的:为研究毫微粒给药系统质量评价,拓宽阿克拉霉素A毫微粒的制剂学内容,制备了阿克拉霉素A聚乳酸毫微粒。方法:采用均匀设计方法设计实验,以界面聚合法制备出阿克拉霉素A聚乳酸毫微粒。结果:得到的毫微粒平均粒径为80nm,平均载药量为18.5%,平均包封率为86.7%。结论:以聚乳酸为载体材料,制备阿克拉霉素A聚乳酸毫微粒的工艺是可行的。

关 键 词:阿克拉霉素A  聚乳酸  毫微粒
收稿时间:1997-04-07;

The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle
He Lin. The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle[J]. Chinese Pharmaceutical Journal, 1998, 33(5): 289-291
Authors:He Lin
Affiliation:(He L),Jiang Xuehua(Jiang XH),Li Tun(Li T
Abstract:
OBJECTIVE: To prepare the poly (DL-lactide) aclacinomycin nanoparticle in order to evaluate the nanoparticle delivery system and to develop the pharmaceutics of aclacinomycin nanoparticle. METHODS: An optimal design was selected to establish the optimal condition, and the interfacial polymerization method was used to prepare the nanoparticle system. RESULTS: The mean diameter of the nanoparticle was 80 nm, the mean drug loading was 18.5%, and the drug embedding ratio was 86.7%. CONCLUSION: The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle is practicable and successful.
Keywords:aclacinomycin A  poly (DL-lactide)  nanoparticle
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