Cellular zinc in patients with diabetes mellitus |
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| Affiliation: | 1. Clinical Chinese Medicine Teaching and Research Office, Hebei University of Chinese Medicine, Shijiazhuang, China;2. Department of 2nd Nephrology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang, China;3. Department of Acupuncture, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China;4. Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia;5. Department of Surgery, Royal Shrewsbury Hospital, Shrewsbury and Telford NHS Trust, Shrewsbury, West Midlands, United Kingdom;6. Huang Di Neijing Teaching and Research Office, Hebei University of Chinese Medicine, Shijiazhuang, China |
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| Abstract: | ![]()
Although hyperzincuria appears to be a common finding in most diabetic subjects, plasma zinc concentration has been reported to be normal, increased, or decreased in these patients. In this study we assayed cellular zinc levels of diabetic subjects in order to assess zinc status. Zinc levels in plasma, lymphocytes, granulocytes, and platelets were lower than in controls. We also observed hyperzincuria in our subjects. The activity of nucleoside phosphorylase a zinc dependent enzyme, was decreased in the lymphocytes. Based on these data we conclude that our diabetic subjects were zinc deficient. |
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