| 醒脑静注射液对老年患者全静脉麻醉恢复期及术后早期认知功能的影响 |
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| 引用本文： | 舒爱华,方海滨,占乐云,张明瑜,余艳丽,吕恩.醒脑静注射液对老年患者全静脉麻醉恢复期及术后早期认知功能的影响[J].中国药房,2010(16):1487-1489. |
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| 作者姓名： | 舒爱华 方海滨 占乐云 张明瑜 余艳丽 吕恩 |
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| 作者单位： | 湖北宜昌市第一人民医院麻醉科; |
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| 摘 要： | 目的:研究醒脑静注射液对老年患者全静脉麻醉恢复期及术后早期认知功能的影响并探讨其可能的作用机制。方法:80例全静脉麻醉下行择期腹部手术的老年患者,随机分为醒脑静组(X组)和对照组(C组),各40例。麻醉诱导前及术后1、3、6及24h应用Mini-MentalState(MMS)测试方法评定其认知功能,并检测各时间点血清S100ββ蛋白及白介素-6(IL-6)含量。结果:2组患者MMS评分均在术后1h最低,X组术后1h较麻醉诱导前明显降低(P<0.05),术后3h开始恢复;C组术后1、3h较麻醉诱导前明显降低(P<0.05),且术后1、3、6h较X组明显降低(P<0.05);2组S100ββ蛋白及IL-6均在术毕最高,C组S100ββ蛋白在术后1、6h高于X组,IL-6在术后1、6、24h均高于X组。结论:醒脑静注射液可以促进全静脉麻醉老年患者的苏醒,改善术后认知功能,可能与其有效抑制S100ββ蛋白及IL-6的分泌、减轻炎性反应有关。
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| 关 键 词： | 醒脑静注射液 认知功能 S100ββ蛋白 白介素-6 |
Effects of Xingnaojing Injection on the Cognitive Function in Elderly Patients in Early Postoperative and Recovery Period after General Intravenous Anesthesia |
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| SHU Ai-hua,FANG Hai-bin,ZHAN Le-yun,ZHANG Ming-yu,YU Yan-li,LV En.Effects of Xingnaojing Injection on the Cognitive Function in Elderly Patients in Early Postoperative and Recovery Period after General Intravenous Anesthesia[J].China Pharmacy,2010(16):1487-1489. |
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| Authors: | SHU Ai-hua FANG Hai-bin ZHAN Le-yun ZHANG Ming-yu YU Yan-li LV En |
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| Institution: | (Dept. of Anesthesiology, Yichang Municipal First People’s Hospital of Hubei Province,Yichang 443000,China) |
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| Abstract: | OBJECTIVE:To investigate the effects of Xingnaojing injection on the cognitive function in elderly patients in early postoperative and recovery period after general intravenous anesthesia. METHODS:80 elderly patients with elective abdominal surgery after general intravenous anesthesia were randomly divided into Xingnaojing group(group X)and control group(group C) with 40 patients in each group. MiniMental State(MMS)detection was used to evaluate cognitive function before anesthesia and at 1 h,3 h,6 h and 24... |
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| Keywords: | Xingnaojing injection Cognitive function S100ββ protein IL6 |
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