甲壳低聚糖对小鼠肠道正常菌群的影响

目的：观察甲壳低聚糖对小鼠肠肠道菌群的影响。方法：取昆明种小鼠20只，随机分为观察和对照组，分别用甲壳低聚糖600mg(kg.d)和等体积的生理盐水灌胃，连续7d，而后检测两组肠道菌群的变化。结果：观察组双歧杆菌数量比对照组明显增多（P＜0．05），乳杆菌数量在两组间无明显差异，观察组大肠杆菌、肠球菌数量较对照组有减少趋势。结论：甲壳低聚糖具有调节小鼠肠道菌群及促进双歧杆菌增殖功能。

Effect of Oligo-chitosan on Normal Intestinal Flora in Mice

Objective: To investigate the effect of olig o-chitosan on nor mal intestinal flora in mice. Methods: Twenty mice were divided randomly into an observed group and a control group. The mice in the observed group we re administered (ig) oligo-chitosan at a dose of 600 mg/(kg*d) for seven da ys. The control group were received the same volume of normal saline for seven d ays. After seven days the levels of intestinal flora were measured. Resul ts: The amount of Bifidobacteria in the observed group obviously increase d as compared with that in the control group ( P<0.05), but the number of La ctobacillus had no significant change. Conclusion: It was indicated that olig o-chitosan could adjust the intestinal flora and could stimulate the proliferat ion of Bifidobacterium in mice efficiently.