| 急性淋巴细胞性白血病的细胞遗传学研究 |
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| 引用本文： | 陈赛娟,曹琪.急性淋巴细胞性白血病的细胞遗传学研究[J].上海交通大学学报(医学版),1993,13(4):277-281. |
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| 作者姓名： | 陈赛娟 曹琪 |
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| 作者单位： | 上海第二医科大学附属瑞金医院血液研究所
(陈赛娟，曹琪，张影梅)，新华医院
(顾龙君)，上海市儿童医院
(钱珠兹)，上海第二医科大学附属瑞金医院血液研究所(陈竺) |
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| 基金项目： | 国家自然科学基金，卫生部青年基金 |
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| 摘 要： | 对40例中国人急性淋巴细胞白血病(急淋)进行了细胞遗传学的研究,发现正常核型为40%,染色体数量异常占42.5%,染色体结构异常为17.5%,特异染色体异常包括有t(9;22)(q34;q11),t(4;11)(q21;q23)和t(8;14)(q24;q32)及环状染色体等.分析了2例急淋患者初发和复发时核型的变化,显示复发时有附加异常。研究认为细胞形态学,免疫表型和细胞遗传学的联合分析(MIC)有助于急淋的诊断和分型。此外,细胞遗传学检查对于急淋白血病的预后具有重要意义。
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| 关 键 词： | 急性 白血病 细胞遗传学 免疫表型 |
Cytogenetic Study on Acute Lymphoblastic Leukemia |
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| Chen Saijuan,et al Institute of Hematology,Ruijin Hospital,Shanghai Second Medical University,Shanghai.Cytogenetic Study on Acute Lymphoblastic Leukemia[J].Journal of Shanghai Jiaotong University:Medical Science,1993,13(4):277-281. |
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| Authors: | Chen Saijuan Institute of Hematology Ruijin Hospital Shanghai Second Medical University Shanghai |
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| Abstract: | A cytogenetic study was performed in 40cases of acute lymphoblastic leukemia (ALL). results showed that in 16 cases (40%) the karyotype was normal in 17 cases (42.4%) quantitative chromosomal abnormalities were identified, and in 7 cases (17.5%) there were structural aberrations. Specific chromosomal anormalies found included translocation t(9;22) (q34;q11), t(4;11) (q21;q23), t(8;14) (q24;q32) and ring chromosome. In 2 cases, karyotype analysis was carried out at the first presentation and at the relapse of the disease, with additional chromosomal abnormalities being found at relapse. It was shown that combined morphologic, immunologic and cytogenetic study (MIC) was valuable for the precise diagnosis and classification of ALL. Cytogenetic study also provided informations independent of other biological parameters in the prognosis of ALL. |
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| Keywords: | acute lymphoblastic leukemia cytogenetics immunophenotype |
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