| 川芎嗪自乳化缓释固体分散体释放度测定方法研究 |
| |
| 引用本文： | 陈道阳,陈晓丹,王利胜.川芎嗪自乳化缓释固体分散体释放度测定方法研究[J].辽宁中医药大学学报,2012(10):103-105. |
| |
| 作者姓名： | 陈道阳 陈晓丹 王利胜 |
| |
| 作者单位： | 广东省人民政府机关门诊部;广州中医药大学中药学院 |
| |
| 基金项目： | 广东省科技计划项目(2010B030700039) |
| |
| 摘 要： | 目的:建立川芎嗪自乳化缓释固体分散体释放度测定方法。方法:采用HPLC法测定川芎嗪自乳化缓释固体分散体中TMP的含量,考察相关因素对其体外释药的影响。结果:以转篮法为溶出度测定方法,释放介质为脱气纯水,转速为50r/min。结论:建立了良好的川芎嗪自乳化缓释固体分散体释放度测定方法,为评价和控制该药的质量提供依据。
|
| 关 键 词： | 川芎嗪 自乳化缓释固体分散体 释放度 |
Study on Release Rate of TMP Self-emulsifying Release Solid Dispersion |
| |
| CHEN Dao-yang,CHEN Xiao-dan,WANG Li-sheng.Study on Release Rate of TMP Self-emulsifying Release Solid Dispersion[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(10):103-105. |
| |
| Authors: | CHEN Dao-yang CHEN Xiao-dan WANG Li-sheng |
| |
| Institution: | 1.Outpatient Department,Guangdong Provincial People’s Government,Guangzhou 510040,Guangdong,China;2.College of Chinese Pharmacy,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China) |
| |
| Abstract: | Objective:To establish release rate determination methods of TMP self-emulsifying release solid dispersion.Methods:HPLC was applied to determine the content of TMP,and different effects on release rate of TMP self-emulsifying release solid dispersion were studied in vitro.Results:The release medium was degassed pure water,the rotation speed was 50r.min-1.Conclusion:A good method to determine release rate of TMP self-emulsifying release solid dispersion was established,providing a basis to evaluate and control the quality of drugs. |
| |
| Keywords: | TMP self-emulsifying release solid dispersion release rate |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
