良性前列腺增生前列腺血管阻力指数与心血管疾病危险因素关系研究

目的:探讨前列腺动脉阻力指数(RI)与心血管疾病危险因素、前列腺体积之间的关系。方法:以145例良性前列腺增生(BPH)患者作为研究对象,评估其心血管危险因素包括高血糖、高血压、血脂异常、肥胖和既往心血管事件共5项,行经直肠超声测量前列腺动脉包括前列腺包膜支、尿道支和神经血管束的阻力指数以及前列腺体积、移行带体积。利用相关分析探讨RI与心血管危险因素、前列腺体积和移行带体积之间的关系。结果:尿道支和左侧神经血管束RI与心血管疾病危险因素数目呈正相关(r=0.247,P=0.013;r=0.215,P=0.039)。尿道支RI和前列腺体积之间(r=0.278,P=0.009),尿道支、包膜支RI和移行带体积之间(r=0.358,P=0.001;r=0.224,P=0.031)呈正相关。结论:BPH患者前列腺动脉系统的阻力指数与心血管疾病危险因素数目、前列腺/移行带体积之间呈正相关,提示BPH的发生与动脉低灌注密切相关,降低前列腺血管阻力可能是防治前列腺增生的一个新的方法。

Research of Correlation between the Resistive Indexes of the Prostatic Arteries and Cardiovascular Risk Factors in Patients with Benign Prostatic Hyperplasia

Objective:To investigate correlations among the resistive indexes(RI) of the prostatic arteries,cardiovascular risk factors and prostate volume in patients with benign prostatic hyperplasia(BPH).Methods:145 BPH patients were included.5 cardiovascular risk factors,including obesity,diabetes,hypertension,hyperlipidemia and a history of cardiovascular events,were evaluated.Transrectal ultrasonography was performed with the patients to measure the RI in the prostate capsular arteries,periurethral arteries and neurovascular bundles,prostate volume and transitional zone volume.The correlations were analyzed among the resistive indexes of the prostatic arteries,the cardiovascular risk factors,prostate volume and transitional zone volume.Results:The resistive indexes of the periurethral arteries and left neurovascular bundles showed positive correlations with the number of cardiovascular risk factors in the patients(r=0.247,P=0.013;r=0.215,P=0.039).The periurethral artery resistive index also correlated positively with prostate volume(r=0.278,P=0.009),and the RI of periurethral arteries and prostate capsular arteries correlated positively with transitional zone volume(r=0.358,P=0.001;r=0.224,P=0.031).Conclusions:RI of prostate arteries in patients with BPH has positive correlations with cardiovascular risk factors and prostate volume/ transitional zone volume,which indicates that prostate underperfusion might play a role in the pathogenesis of BPH.It may be a new strategy of reducing vascular resistance to prevent and treat BPH.