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| 大剂量旋覆代赭汤治疗脾胃虚弱型糖尿病胃轻瘫临床观察 | |
| 引用本文： | 贾锐馨,李国永,席洪涛,仪晓辉,崔军,彭定国. 大剂量旋覆代赭汤治疗脾胃虚弱型糖尿病胃轻瘫临床观察[J]. 辽宁中医药大学学报, 2012, 0(9): 114-115 |
| 作者姓名： | 贾锐馨 李国永 席洪涛 仪晓辉 崔军 彭定国 |
| 作者单位： | 河北赵县中医院内一科;白求恩国际和平医院;湖北宜昌夷陵医院 |
| 基金项目： | 河北省中医药管理局中医药类科研课题(2011138) |
| 摘 要： | 目的:观察旋覆代赭汤对糖尿病胃轻瘫(Diabetic gastroparesis,DGP)患者促胃肠动力作用量效关系研究。方法:将108例脾胃虚弱型患者随机分为治疗组:大剂量54例(一两为15.625g)和对照组54例,对照组药物口服吗丁啉,10mg,每日3次,连用4周;治疗组药物口服旋覆代赭汤,每日1剂,连用4周。免疫组化法观察治疗前后血浆中胃动素(MOT)、血管活性肠肽(VIP)、胃泌素(GAS)的分布变化。结果:治疗组血浆中MOT的含量显著升高(P<0.01)、VIP的表达明显减少(P<0.01)、显著降低血浆GAS表达(P<0.05)。结论:旋覆代赭汤的促胃肠动力作用可能与血浆中MOT的含量显著升高和VIP与GAS的表达降低有密切关系。 |
| 关 键 词： | 糖尿病胃轻瘫 旋覆代赭汤 胃动素 血管活性肠肽 胃泌素 |
Clinical Observation of Treating DGP due to Kidney Weakness by Large Dose of Xuanfu Daizhe Decoction |
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| JIA Rui-xin,LI Guo-yong,XI Hong-tao,YI Xiao-hui,CUI Jun,PENG Ding-guo. Clinical Observation of Treating DGP due to Kidney Weakness by Large Dose of Xuanfu Daizhe Decoction[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2012, 0(9): 114-115 | |
| Authors: | JIA Rui-xin LI Guo-yong XI Hong-tao YI Xiao-hui CUI Jun PENG Ding-guo |
| Affiliation: | 1.First Internist Department of Zhaoxian Hospital of Traditional Chinese Medicine,Zhaoxian 051530,Hebei,China;2.Bethune International Peace Hospital,Shijiazhuang 050000,Hebei,China;3.Yingchang Yiling Hospital of Hubei Province,Yingchang 443100,Hubei,China) |
| Abstract: | Objective:To research the relationship between Xuanfu Daizhe Decoction dose and its effect on improving DGP patients’ gastrointestinal motility due to kidney weakness.Method:108 DGPs due to kidney and spleen weakness were randomly divided into two groups;54 treated by a large dose(1 liang=15.625g);54 DGP patients as compared treated by oral administration of Domperidone,10mg for each time,3 times a day,consectutively for 4 weeks.The distribution changes of MOT,VIP and GAS in plasmas were observed by the method of immunohistochemistry.Result:For the large-dose group,percentage of MOT in plasmas increased notably(P<0.01),VIP expression decreased notably(P<0.01),GAS expression in plasmas decreased notably(P<0.05).Conclusion:Xuanfu Daizhe Decoction’s function on improving DGP’s gastrointestinal motility may be connected closely with the in-plasmas MOT’s notable increase and the decreased expressions of VIP and GAS. |
| Keywords: | DGP Xuanfu Daizhe Decoction Motilin vasoactive intestinal peptide gastrinoma |
| 本文献已被 CNKI 等数据库收录！ | |