| 不同银杏内酯化合物抗血小板活聚集(PAF)活性的研究 |
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| 引用本文： | 廖华军,郑云枫,李红阳,彭国平.不同银杏内酯化合物抗血小板活聚集(PAF)活性的研究[J].辽宁中医药大学学报,2012(10):63-65. |
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| 作者姓名： | 廖华军 郑云枫 李红阳 彭国平 |
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| 作者单位： | 南京中医药大学药学院;福建中医药大学药学院 |
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| 基金项目： | 福建省科技厅资助项目(2012J05151) |
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| 摘 要： | 目的:探讨不同银杏内酯化合物对家兔血小板聚集作用的影响。方法:进行体外实验观察不同银杏内酯化合物对由血小板活化因子(PAF)诱导的家兔血小板聚集作用的影响。结果:不同银杏内酯化合物体对PAF诱导的血小板聚集均有抑制作用,IC50在0.24～27.44μg/mL之间。结论:不同银杏内酯化合物体外对血小板聚集均有抑制作用差异明显。
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| 关 键 词： | 银杏内酯 血小板聚集 血小板活化因子 |
Study on Antinplatelet Aggregation Activity Induced by PAF of Ginkgolide Compounds |
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| LIAO Hua-jun,ZHENG Yun-feng,LI Hong-yang,PENG Guo-ping.Study on Antinplatelet Aggregation Activity Induced by PAF of Ginkgolide Compounds[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(10):63-65. |
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| Authors: | LIAO Hua-jun ZHENG Yun-feng LI Hong-yang PENG Guo-ping |
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| Institution: | 1(1.College of Parmacy,Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;2.College of Parmacy,Fujian University of Chinese Medicine,Fuzhou 350122,Fujian,China) |
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| Abstract: | Objective:To observe the effects of antinplatelet aggregation activity induced by PAF of ginkgolide compounds.Methods:The activity of seven ginkgolide compounds had been evaluated on rabbit platelet aggregation induced by PAF in vitro,and the IC50 value were calculated.Results:Each ginkgolides had displayed different intensity activities,the IC50 value of which were between 0.24 and 27.44μg/mL.Conclusion:The experiment result had indicated that the difference of antinplatelet aggregation activity induced by PAF of ginkgolide compounds was obvious due to structure difference. |
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| Keywords: | ginkgolide antinplatelet aggregation activity platelet-activating factor |
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