深圳市宝安区妊娠梅毒患者性伴梅毒感染情况及影响因素分析

目的了解妊娠梅毒患者性伴梅毒感染情况及其影响因素。方法对确诊的妊娠梅毒患者进行性伴通知,对就诊的性伴进行甲苯胺红不加热血清试验(tolulized red unheated serum test,TRUST)和梅毒螺旋体颗粒凝集试验(teponema pallidum purtide assay,TPPA)检测,通过问卷收集性伴基本人口学及既往病史信息;采用多因素Logistic回归模型分析性伴梅毒感染的影响因素。结果 2012-2016年间,深圳市宝安区共确诊妊娠梅毒患者1 074例,788例(73.37%)性伴就诊并自愿进行了梅毒血清检测;其中TRUST和TPPA均阳性137例,既往规范治疗后仅TPPA阳性26例,性伴梅毒感染率为20.69%。多因素Logistic回归分析发现妊娠梅毒患者年龄≥40岁(OR=2.21,95%CI:1.26～3.88,P=0.006)、血清TRUST滴度>1∶8(OR=2.81,95%CI:1.81～4.39,P=0.000)以及性伴为少数民族(OR=3.65,95%CI:1.39～9.60,P=0.009),性伴更趋向于感染梅毒。结论妊娠梅毒患者的性伴具有较高的梅毒感染率,孕产妇年龄≥40岁、血清TRUST滴度水平≥1∶8、性伴为少数民族是性伴感染梅毒的危险因素。

Analysis on Syphilis Infection and Factors Among Partners of Pregnant Syphilis Patients in Baoan District of Shenzhen

Objective To Analysis the syphilis infection rate and factors among spouse/sexual partners of pregnant syphilis patients. MethodsPartner was analised by both tolulized red unheated serum test,TRUST) and teponema pallidum purtide assay,TPPA). The information about social demography and medical history were collected. The resultswere analyzed using multiariable logistic regression model. ResultsFrom 2012 to 2016,a total of 1074 pregnant syphilis were identified in baoan district of Shenzhen,and 788 partners attended to the antenatal care hospital to take in syphilis serological test with a rate of 73.37%. There were 137 partners were positive for TRUST and TPPA,and 26 partners positivefor only TPPA after precious treatment,giving a syphilis infection rate of 20.69%. Partners of those pregnant women more than 40 years old(OR=2.21,95%CI:1.26~3.88,P=0.006)and with a serum TRUST titer more than 1∶8 (OR=2.81,95%CI:1.81~4.39,P=0.000),and partners with minority nationality identity(OR=3.65,95%CI:1.39~9.60,P=0.009),were more likely to be infected with syphilis . ConclusionSyphilis infection rate among partners of pregnant syphilis patients was high. Age and serum TRUST titer of pregnant women and minority nationality associated with partners′ syphilis infection.