依达拉奉对单肺通气患者围术期细胞因子IL-6、IL-8及其mRNA表达的影响

目的：观察依达拉奉对单肺通气患者围术期炎性细胞因子IL-6、IL-8及其mRNA表达的影响。方法：择期拟行肺叶切除术肺癌患者24例，ASAⅠ级或Ⅱ级，年龄48～67岁，随机分为2组：对照组（C组）和依达拉奉组（E组），每组12例。麻醉诱导：两组均静脉注射咪唑安定0．03mg／kg、芬太尼3μg／kg，吸入8％七氟醚。麻醉诱导后，E组给予依达拉奉0．5mg／kg；C组给予等量生理盐水。麻醉维持：间断静脉注射维库溴铵0．04～0．08mg／kg、芬太尼0．05～0．1mg，七氟醚呼气末浓度维持在1．8％～2．7％。两组均在麻醉后切皮前（T1）、膨肺后60min（T2）、术后1h（T3）采取血样测定白细胞介素IL-6、IL-8血浆浓度及其mRNA表达。结果：与T4比较，两组IL-6、IL-8血浆浓度及其mRNA表达于T2—3明显上升（P〈0．05）；与C组相比，E组IL-6、IL-8血浆浓度及其mRNA表达于T2-3显著低于C组（P〈0．05）。结论：依达拉奉应用于单肺通气患者可有效抑制机体促炎细胞因子的生成和释放。

Effects of edaravone on interleukin -6, -8 and expression of their mRNA in patients undergoing one lung ventilation

AIM： To investigate the effects of edaravone on interleukin（IL） -6, -8 and expres sion of their mRNA in patients undergoing one lung ventilation （OLV）. METHODS： Twenty-four ASA I or II patients with lung cancer of both sexes aged 48- 67 yr undergoing elective lung resection were randomly divided into two groups （n=12 each）： Control group （C） and Edaravone group （E）. Anesthesia was induced with midazolam 0.03 mg/kg, Fentanyl 3μg/kg and 8% Sevoflurane, and maintained with intermittent i. v. boluses of vecuronium 0.04--0.08 mg/kg, Fentanyl 0.05 -- 0.1 mg and 1.8% -- 2.7% Sevoflurane in two groups. Group E was received edaravone 0.5 mg/kg after induction of anesthesia. Blood sample were taken before skin incision （T1）, 60 rain after lungs were inflated （T2）and 1 h after surgery（T3） for determination of plasma IL-6, IL-8 concentration and expression of their mRNA. RESULTS： The levels of IL-6, IL-8 and their mRNA were all significantly increased at T2-3 in both group than at T1 （P〈0.05）; but the levels of IL-6, IL-8 and their mRNA were lower at T2-3 in group E than those in group C（P〈0.05）. CONCLUSION： Edaravone is effective in reducing inflammatory response in patients undergoing OLV.