| Caspase-1抑制剂对大鼠局灶脑缺血再灌注后神经元损伤的影响 |
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| 引用本文： | 王涛,陈莉,文亮.Caspase-1抑制剂对大鼠局灶脑缺血再灌注后神经元损伤的影响[J].脑与神经疾病杂志,2005,13(5):348-350. |
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| 作者姓名： | 王涛 陈莉 文亮 |
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| 作者单位： | 400038,重庆第三军医大学西南医院ICU;400038,重庆第三军医大学西南医院ICU;400038,重庆第三军医大学西南医院ICU |
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| 摘 要： | 目的：研究YVAD-FMK(Caspase-1抑制剂)对大鼠局灶脑缺血再灌注后神经元损伤的影响。方法：采用大鼠局灶脑缺血再灌注模型，动态测量脑组织中IL—1β含量、脑含水量及血清NSE含量的变化以及YVAD-FMK对上述指标的影响。结果：YVAD-FMK能够减少脑组织IL-1β的含量，减轻脑水肿及能显著降低血清NSE升高的幅度。结论：YV4D-FMK对局灶脑缺血再灌注后神经元的损伤具有保护的作用。
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| 关 键 词： | 脑缺血/再灌注损伤 白介素-1β转化酶抑制剂 脑水肿 白介素-1β |
| 文章编号： | 1006-351X（2005）05-0348-03 |
| 收稿时间： | 2005-06-14 |
| 修稿时间： | 2005年6月14日 |
Effects of YVAD-FMK on focal cerebral ischemia-reperfusion injury in rats |
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| WANG Tao,CHEN Li,WEN Liang.Effects of YVAD-FMK on focal cerebral ischemia-reperfusion injury in rats[J].Journal of Brain and Nervous Diseases,2005,13(5):348-350. |
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| Authors: | WANG Tao CHEN Li WEN Liang |
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| Institution: | Department of third Military Medical University, Chongqing, 400038, China |
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| Abstract: | Objective: The effects of YVAD-FMK (Caspase-1 inhibitor) on neuron damage after focal cerebral ischemia—reperfusion injury in rats were studied. Methods: Using a rat model with thread embolish of middle cerebral artery, the effects of YVAD-FMK on the changes of level of IL-1 1β and the content of water in brain tissues and the content of NSE (neuron specific enolase) in serum were dynatrdcally observed. Results: YVAD-FMK could reduce the level of IL-1 β and decrease brain edema and the ascending degree of the content of NSE in serum Conclusion: YVAD-FMK has a good protective effects on cerebral neuronal damage induced by focal cerebral ischemia—reperfusion injury in rats. |
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| Keywords: | Cerebral ischemia Reperfusion injury Caspase inhibiting Brain edema IL-1β NSE |
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