| 约束应激对大鼠5-HT1A和5-HT2A受体表达的影响 |
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| 引用本文： | 吴兴曲,杨来启,王晓峰,李拴德,马文涛,杨喜民,刘光雄,王倩云,张红宾.约束应激对大鼠5-HT1A和5-HT2A受体表达的影响[J].中国临床心理学杂志,2003,11(3):225-227. |
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| 作者姓名： | 吴兴曲 杨来启 王晓峰 李拴德 马文涛 杨喜民 刘光雄 王倩云 张红宾 |
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| 作者单位： | 解放军第三医院精神科,陕西,宝鸡,721004 |
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| 摘 要： | 慢性应激如长期压抑 ,环境不适等易导致身心健康损害 ,出现学习记忆、情绪行为等多方面的改变1,2 ] ,目前对其发生机制的研究多集中在下丘脑 -垂体 -肾上腺 (HPA)轴、自主神经系统和免疫系统等 ,而对 5 -羟色胺 (5 -HT)的研究较少。 5 -HT是一种重要的中枢神经递质 ,参与多种行为、情绪活动的调节 ,迄今已发现了 5 -HT受体的 7种类型 13个亚型。近来的研究报道认为 5 -HT1A 和 5 -HT2A 可能与精神机能和学习记忆有关3 ,4] 。为探讨慢性应激与 5 -HT1A、5 -HT2A 受体的关系 ,我们采用PCR观察大鼠经 30天慢性约束应激后不同脑区 5…
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| 关 键 词： | 约束应激 大鼠 5-HT1A 5-HT2A受体 5-羟色胺 动物模型 |
| 文章编号： | 1005-3611(2003)03-0225-03 |
| 修稿时间： | 2002年10月10 |
Effect of Movement Restrict on the Expression of 5-HT Receptor Subtypes in Rat Brain |
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| WU Xing-qu,YANG Lai-qi,WANG Xiao-feng,et al.Effect of Movement Restrict on the Expression of 5-HT Receptor Subtypes in Rat Brain[J].Chinese Journal of Clinical Psychology,2003,11(3):225-227. |
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| Authors: | WU Xing-qu YANG Lai-qi WANG Xiao-feng |
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| Institution: | WU Xing-qu,YANG Lai-qi,WANG Xiao-feng,et al Department of Psychiatry,3 rd Hospital of PLA,Baoji 721004,China |
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| Abstract: | Objective:To explore the 5-HT mechanism of stress . Methods:The method of polymerase chain reaction (PCR) was used to detect the presence of 5-HT receptor subtypes in the hippocampus,hypothalamic and midbrain of the rat after 30days of movement restrict compared with normal cage control groups (CC) . The specific oligonucleotide primers were synthesized based on the complementary DNA sequence for each of the rat 5-HT 1A and 5-HT 2A receptor subtypes . Results : The expression of 5-HT 1A receptor subtypes in each regions of the rat brain after movement restrict were signifcantly lower than that of the CC groups, and the expression of 5-HT 2A receptor subtype were signifcantly higher( P <0.01-0.05).Conclusions : 5-HT 1A and 5-HT 2A receptors may be invovled in the stress of the rat and may have opposite effects with respect to certain functions. |
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| Keywords: | Stress Rat 5-HT receptor PCR |
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