| 马拉色菌属RAPD基因分型与相关疾病的关系 |
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| 引用本文： | 郑义,王玮臻,刘梦琼,夏清,段逸群.马拉色菌属RAPD基因分型与相关疾病的关系[J].武汉大学学报(医学版),2002,23(1):56-58,68. |
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| 作者姓名： | 郑义 王玮臻 刘梦琼 夏清 段逸群 |
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| 作者单位： | 1. 武汉市第一医院皮肤科,武汉,430022
2. 海南省人民医院检验科,海口,570311 |
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| 基金项目： | 中华医学会皮肤科分会科研基金资助项目 (112 ) |
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| 摘 要： | 目的 :探讨马拉色菌属在临床疾病中的意义。方法 :利用RAPD对临床分离株进行基因分型 ,建立马拉色菌属带型关系树状图 ,分析与相关疾病的对应关系。结果 :临床标本可分成 6类 ,其中 5类可进一步分为亚类。各类与疾病无明显的对应关系 ,但可得到具有临床意义的结果。结论 :RAPD作为研究马拉色菌属基因多态性的工具 ,马拉色菌属在相关疾病中存在多样性
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| 关 键 词： | 马拉色霉菌属 聚合酶链反应 基因型 皮肤真菌病病因学 |
The Relationship of RAPD Genotypes of Malassezia and Related Diseases |
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| Zheng Yi,Wang Weizhen,Liu Mengqiong,et al.The Relationship of RAPD Genotypes of Malassezia and Related Diseases[J].Medical Journal of Wuhan University,2002,23(1):56-58,68. |
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| Authors: | Zheng Yi Wang Weizhen Liu Mengqiong |
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| Institution: | Zheng Yi,Wang Weizhen,Liu Mengqiong,et al Department of Dermatology,Wuhan Hospital,Wuhan 430022,China |
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| Abstract: | Objective:To study the meaning of Malassezia in clinical diseases. Methods:clinical isolates using RAPD (random amplified polymorphic DNA)were genotyped and established DNA banding pattern dendrogram to analyze the corresponding relationship between them and related diseases. Results:The result showed that all clinical samples were divided into 6 groups, five of which were further devided into subgroups. Significantly clinical value results were obtained in spite of no obvious corresponding relationships among them. Conclusion: RAPD can be used to study gene polymorphic of Malassezia and epidemiologic investigation for related diseases. |
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| Keywords: | Malassezia polymerase chain reaction genotype dermatomycoses/ET |
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