Metabolic acidosis in patients receiving anticonvulsants |
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| Authors: | Bunsaku Nagai Ichiro Matsuda Takahito Kondo Naoyuki Taniguchi Shinichiro Arashima Takashi Mitsuyama Yogo Oka Masakatsu Honma |
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| Affiliation: | (1) Department of Pediatrics and Department of Medicine, Hokkaido University School of Medicine, Hokkaido, Japan;(2) Department of Environmental Medicine, Hokkaido University, Graduated School of Environmental Science, Hokkaido, Japan;(3) Department of Pediatrics, Kumamoto University, Medical School, 860 Kumamoto, Japan |
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| Abstract: | ![]()
Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.This research was supported by Shimabara Science Promotion Foundation, 1978 |
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| Keywords: | Anticonvulsants Metabolic acidosis Hypocalcemia Carbonic anhydrase |
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