乙醛脱氢酶1A1在胃癌组织中的表达及其临床意义

目的 探讨乙醛脱氢酶1A1（ALDH1A1）在胃癌组织中的表达及临床意义。方法 采用免疫组化法检测1072例胃癌组织及配对癌旁组织中ALDH1A1的表达，并分析其与临床病理特征及总生存时间（OS）的关系。结果 ALDH1A1在胃癌组织中的阳性表达率为49.9％（535/1072），在癌旁组织中为43.3％（465/1072），差异有统计学意义（P＜0.05）。 ALDH1A1在胃癌组织中的表达与年龄、浸润深度、分化程度、淋巴结转移及TNM分期有关（P＜0.05）。全组患者的中位OS为32.2个月。ALDH1A1阳性表达者为23.3个月，低于阴性表达者的60.4个月（P＜0.001）。Cox多因素分析显示，ALDH1A1表达、分化程度、TNM分期、年龄、淋巴结转移、癌栓、浸润深度和神经侵犯是影响OS的独立因素。结论ALDH1A1在胃癌组织中表达上调，且与胃癌患者预后相关，有可能成为反映胃癌预后新的肿瘤标志物。

Expression of aldehyde dehydrogenase 1A1 in human gastric cancer and its clinical significance

Objective To detect the expression of aldehyde dehydrogenase 1A1 （ALDH1A1） in gastric cancer tissues and clinical significance. Methods ALDH1A1 expression in 1072 gastric cancer tissues and para-caeinoma tissues was detected by immu- nohistochemistry. The associations of ALDHIAI with clinicopathological characteristics and overall survival（OS） were subsequently as- sessed. Results The positive expression rates of ALDH1A1 in gastric cancer tissues and para-cacinoma tissues were 49. 9% （ 535/ 1072） and 43.3% （ 465/1072）, with statistic significance （ P〈0. 05） .The expression of ALDH1A1 was associated with age, depth of gastic wall invasion, differentiation, lymph node metastasis and TNM stage（P〈0.05）. The median OS of 1072 patients was 32. 2 months, and for the patients with positive expression and negative expression of ALDH1A1 were 23.3 and 60. 4months （ P〈 0. 001 ）. Cox multivariate regression model revealed that ALDHIA1 expression, differentiation, TNM stage, age, lymph node metastasis, tumor thrombus, depth of gastic wall invasion and nervous invasion were independent factors influencing OS. Conclusion ALDH1A1 is obvi- ously up-regulated in gastric cancer tissues, and correlated with poor prognosis, which may become a new tumor maker for predicting prognosis of gastric cancer.