胃印戒细胞癌临床病理特征和生物标志的研究现状

胃印戒细胞癌占原发性胃癌的3.4％～39％，是一种含有大量黏液的特殊胃癌类型，具有恶性程度高、分化差、胃壁内弥漫浸润性生长、进展速度快、预后差的特点。除了早期诊断、尽早手术切除外，放化疗等治疗策略对印戒细胞癌的控制均不理想。近年来发现胃印戒细胞癌具有特殊的生物学特征，长期以来人们对其认识并不十分科学。因此，本文将近年来胃印戒细胞癌相关的临床病理特征和生物标志等内容作一综述，以期为其诊断和治疗提供新的思路与策略。

The clinicopathological and biological characteristics of gastric signet ring cell carcinoma

Signet ring cell carcinoma（SCC） is a special form of adenocarcinoma with a large vacuole full of mucin displacing the nucleus to the periphery. The frequency of gastric signet ring cell carcinoma is about 3.4%-39%. With the characteristics of high degree of malignancy, poor differentiation, intramural diffuse infiltrative growth and rapid progression, the prognosis of SCC is quite poor. It is also resistant to chemotherapy and radiotherapy. Recently, it has been found that SCC has certain biological characteristics which differs it from other type adenocarcinoma. Those biological characteristics can be potential biomarkers and targets for therapy. In the current review, we summarize the clinicopathological and biological characteristics of SCC, which may aim at the therapy of it.