Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions |
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| Authors: | Peter R. EASTWOOD Atul MALHOTRA Lyle J. PALMER Eric J. KEZIRIAN Richard L. HORNER Mary S. IP Robert THURNHEER Nick A. ANTIC David R. HILLMAN |
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| Affiliation: | 1. West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital,;2. School of Anatomy and Human Biology, University of Western Australia,;3. Harvard Medical School Medical Director Sleep Disorders Research Program, Brigham and Women's Hospital, Boston, Massachusetts, USA,;4. Centre for Genetic Epidemiology and Biostatistics, University of Western Australia,;5. Division of Sleep Surgery, Otolaryngology—Head and Neck Surgery, University of California, San Francisco, California, USA,;6. Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada,;7. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China, and;8. Kantonsspital Münsterlingen, Münsterlingen, Switzerland;9. Adelaide Institute for Sleep Health and Flinders Medical Centre, Adelaide, South Australia, Australia,;10. West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Perth, Western Australia, |
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| Abstract: | ![]()
Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets. |
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| Keywords: | pathogenesis treatment sleep apnoea syndrome |
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