肺癌患者化疗前后血小板参数动态变化及黄芪注射液的影响

目的:探讨血小板参数在肺癌患者化疗前后的变化及黄芪注射液对血小板参数的影响。方法:回顾性分析55例分别采用单纯化疗和化疗加黄芪注射液治疗的肺癌患者,2组患者均采用日本Sysmex XT-1800i型全自动血液分析仪检测化疗前后血小板(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)等血小板参数,观察并比较血小板参数在肺癌患者化疗前后的变化及单纯化疗组与化疗加黄芪注射液组间的差异。以30例健康体检者作对照。结果:肺癌患者PLT、MPV、PCT较正常人高(P<0.01),而PDW差异没有显著性(P>0.05)。单纯化疗后肺癌患者PLT、MPV、PCT明显下降,其最低值与化疗前比较有显著差异(P<0.01),PDW无明显变化(P>0.05);化疗第21天,PLT、MPV、PCT、PDW值升高,与化疗最低值比较有显著性差异(P<0.05)。化疗加黄芪组血小板下降最低值、MPV及PCT值明显高于单纯化疗组(P<0.05),化疗第21天恢复期PLT、PCT高于单纯化疗组(P<0.05),而PDW、MPV变化不如单纯化疗组明显(P>0.05)。结论:检测血小板参数对于了解肺癌化疗患者骨髓造血情况有一定意义。应用黄芪注射液能保护骨髓造血功能,防止严重血小板减少症的发生。

Changes of platelet Parameter in Patients with Lung Cancer Treated by Chemotherapy and Effects of Astragalus Membranaceus Injection

Objective:To investigate the changes of platelet parameter in patients with lung cancer treated by chemotherapy and the effects of Astragalus membranaceus injection (AMI) on platelet parameter. Methods:55 cases with lung cancer were investigate retrospectively and their platelet parameter were measured by Sysmex XT-1800i automatic blood cell analyzer, including the platelet total (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW).Among the 55 cases,24 treated by chemotherapy only(chemotherapy group) and the others by chemotherapy combianed AMI(chemotherapy AMI group). Then to observe and compare the changes of their platelet parameter. 30 normal adults was taken for control group. Results: PLT, MPV and PCT in patients with lung cancer were significantly lower than normal adults(P <0.01), but PDW were no diffirence (P >0.05). The nadir of PLT, MPV and PCT in patients with lung cancer were decreased significantly after treated by chemotherapy(P <0.01), but PDW were no diffirence (P >0.05). PLT, MPV, PCT and PDW on day 21 after chemotherapy were higher than the nadir(P <0.05). The nadir of PLT ,MPV and PCT of chemotherapy AMI group were significantly higher than chemotherapy group and PLT, PCT on day 21 after chemotherapy were higher than chemotherapy group too (P <0.05). MPV and PDW on day 21 after chemotherapy in chemotherapy AMI group were no diffirence compared with chemotherapy group (P >0.05). Conclusions:it is significant to detect platelet parameter for getting the message of marrow haematopoiesis of patients with lung cancer treated by chemotherapy. AMI can protect function of marrow haematopoiesis and prevent severe plate-reduction.