纳美芬和纳洛酮对急性重度乙醇中毒疗效比较

目的：探讨纳美芬和纳洛酮对急性重度乙醇中毒的疗效,为临床用药提供参考。方法：将2012年1月-2013年12月我院急诊科收治急性重度乙醇中毒患者110例,分为两组,治疗组和对照组各55例,治疗组在常规治疗基础上给予盐酸纳美芬治疗;对照组在常规治疗基础上给予纳洛酮治疗,观察并比较两组患者观察患者治疗后30分、60分钟、90分钟和150分钟神志意识恢复情况。结果：总有效率和显效率比较,治疗后30分钟、60分钟、90分钟和150分钟治疗组均优于对照组。结论：纳美芬对急性重度乙醇中毒患者进行治疗相比纳洛酮具有更为显著的临床疗效,能够明显加快药效起作用时间,减少症状的缓解和消退时间,具有且不良反应少特点,可以在基层临床上推广应用。

The effect comparison of Nalmefene and Naloxone in treating acute alcoholic intoxication

Objective：To explore the difference therapeutic effects of Nalmefene Naloxone in treating acute alcoholic intoxication patients and provide reference for clinical medication.Methods：110patients with acute alcoholic intoxion in our hospital emergency department from January 2012 to December 2013 were randomly divided into treatment group（55cases）with Nalmefene and control group with naloxone（55cases）.The patients in the control group were received routine and naloxone treatment,while patients in the routine treatment group were treated with Nalmefene.The recovery side effect after treatment were observed after 30 minutes,60minutes,90 minutes and 150 minutes.Results：The total effective rate and the efficiency were compared after 30 minutes,60minutes,90 minutes and 150 minutes.The patients in the treatment group recoveryed quickly than the control group（P〈0.05）.Conclusion：Nalmefene is safe effective and less adverse reaction for acute alcoholic intoxication patients thus its clinical use is worthy of recommendation.