Association of hemoglobin glycation index with outcomes of acute ischemic stroke in type 2 diabetic patients |
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| Authors: | Yuesong Pan Jing Jing Yongjun Wang Liping Liu |
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| Affiliation: | 1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China;2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China;3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;4. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;5. China National Clinical Research Center for Neurological Diseases, Beijing, China;6. Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China;7. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China |
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| Abstract: | Objective This study aimed to investigate the association between the hemoglobin glycation index (HGI) and the prognosis of diabetic patients with ischemic stroke.Methods Data were derived from the Abnormal Glucose Regulation in Patients with Acute Stroke across China (ACROSS-China) registry. Diabetic patients with ischemic stroke were included. HGI was calculated by subtracting the predicted HbA1c based on fasting plasma glucose from the observed HbA1c, and then classified into three groups by the tertiles: low HGI (Results A total of 976 diabetic patients were included. Low HGI was associated with an increased risk of stroke recurrence and poor outcome (adj.hazard ratio 1.53, 95% confidence intervals (CIs) 1.11–2.12, p = 0.01; and adj.odds ratio 1.64, 95% CI 1.13–2.38, p = 0.01, respectively), and high HGI was associated with an increased risk of poor outcome (adj.odds ratio 1.54, 95% CI 1.06–2.24, p = 0.02), compared with moderate HGI. We found a U-shaped association between HGI and the prognosis.Conclusion Both low HGI and high HGI was associated with an increased risk of poor prognosis in diabetic patients with ischemic stroke, compared with moderate HGI. |
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| Keywords: | Diabetes mellitus hemoglobin A1c ischemic stroke outcome |
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