血栓素、前列环素与运动后蛋白尿生成机制的实验研究

以大鼠为实验对象，测定安静时、大强度间歇负重游泳运动后即刻及运动后休息４５分钟时血浆血栓烷Ｂ_２（ＴＸＢ_２）、６－酮－前列腺素Ｆ_（１２）（６－ｋｅｔｏ－ＰＧＦ_（１２））的浓度变化及尿总蛋白（ＴＰ）、白蛋白（Ａｌｂ）、β_２微球蛋白（β_２－ｍＧ）排泄率变化，以期为运动后蛋白尿的生成机制提供实验材料。结果表明：运动后即刻血浆ＴＸＢ_２、６－ｋｅｔｏ－ＰＧＦ_（１２）明显高于对照组（Ｐ＜０．０５；Ｐ＜０．０１），尿ＴＰ、Ａｌｂ、β_２－ｍＧ排泄率也呈非常显著的升高。运动后休息４５分钟时血浆ＴＸＢ_２及尿ＴＰ、Ａｌｂ、β_２－ｍＧ均呈不同程度的减少。相关分析表明ＴＸＢ_２、ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_（１２）比值与尿ＴＰ、Ａｌｂ、β_２－ｍＧ之间呈高度正相关；虽然６－ｋｅｔｏ－ＰＧＦ_（１２）与尿ＴＰ、Ａｌｂ、β_２－ｍＧ之间呈负相关，但无明显统计意义（Ｐ＞０．０５）。提示血栓素，前列环素的变化可能是运动后蛋白尿生成机制中的一个重要因素。

An Experimental Study of Effect of Thromboxane A and Prostacyclin on the Mechanisms of Postexercise Proteinuria in Rats

In order to investigate the mechanisms of postexercise proteinuria,plasma thromboxane B_2(TXB_2),6-keto-prostaglandin F_(12)(6-keto-PGF_(11)and urinary total protein(TP),albumin(Alb),B_2- microglobulin(β_2-mG) in rats were determined at rest,immediately after interval heavy swimming and 45 minutes after exercise.The results showed that plasma TXB_2 6-keto-PGF_(12)and urinary TP,AIb,B-mG increased significantly immediately after acute exercise and decreased respectively 45 minutes after exercise.The study indicated that there were significantly positive correlations of TXB_2,TXB_2/6-keto-PGF_(12) ratio to urinary TP,Alb and β_2-mG.Negative correlation of 6-keto-PGF￣(12)to urinary TP,Alb and β_2-mG was observed without statistic differences(p<0.05). It was suggested that the changes of thromboxane A_2 and prostacyclin might be the important factors in mechanisms of postexercise proteinuria.