| 一氧化氮生物利用度失调与动脉粥样硬化 |
| |
| 引用本文： | 陈静宜,叶子芯,崔姝雅,王秀芬,洪芬芳,杨树龙.一氧化氮生物利用度失调与动脉粥样硬化[J].基础医学与临床,2017,37(2). |
| |
| 作者姓名： | 陈静宜 叶子芯 崔姝雅 王秀芬 洪芬芳 杨树龙 |
| |
| 作者单位： | 1. 南昌大学医学部基础医学院生理教研室,江西南昌,330006;2. 南昌大学医学部医学实验教学中心,江西南昌,330006 |
| |
| 基金项目： | 国家自然科学基金(81660751，81660151，81260504)；江西省重点研发计划项目(20161BBG70067)；南昌大学教学改革研究课题(NCUJGLX-14-1-111)；南昌大学科研训练项目(349，351，569)；南昌大学创新创业训练项目 |
| |
| 摘 要： | 内皮功能障碍与动脉粥样硬化(AS)密切相关。氧化应激、脂质浸润、炎性反应因子表达及血管张力改变等涉及一氧化氮(NO)生物利用度(内源性NO的生成和利用)的降低,在内皮功能障碍中发挥重要作用。精氨酸酶活性增强、非对称性二甲基精氨酸和同型半胱氨酸增加均能使NO生物利用度下降,促进AS发生发展。糖尿病、肥胖、慢性肾病和吸烟等通过多种方式影响NO生物利用度,参与AS的发生。
|
| 关 键 词： | 动脉粥样硬化 内皮功能障碍 一氧化氮 一氧化氮合酶 一氧化氮生物利用度 |
Nitric oxide bioavailability dysfunction and atherosclerosis |
| |
| CHEN Jing-yi,YE Zi-xin,CUI Shu-ya,WANG Xiu-fen,HONG Fen-fang,YANG Shu-long.Nitric oxide bioavailability dysfunction and atherosclerosis[J].Basic Medical Sciences and Clinics,2017,37(2). |
| |
| Authors: | CHEN Jing-yi YE Zi-xin CUI Shu-ya WANG Xiu-fen HONG Fen-fang YANG Shu-long |
| |
| Abstract: | Endothelial dysfunction was closely related with AS , NO bioavailability ( production and utilization of endothelial NO ) was decreased by oxidative stress , lipid infiltration , inflammatory factor expression , vascular tone alteration and so on , which play an important role in endothelial dysfunction .Enhanced arginine , activityand asym-metric dimethylarginine together with increased hyperhomocysteinemia all promote AS by intervening NO bioavail -ability.Diabetes mellitus, obesity, chronic kidney disease , smoking and so on also involved in AS via influencing NO bioavailability and NO level . |
| |
| Keywords: | atherosclerosis endothelial dysfunction nitric oxide nitric oxide synthase NO bioavailability |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
