支气管哮喘患儿吸入丙酸氟替卡松疗效观察

目的:观察哮喘患儿吸入丙酸氟替卡松(FP)治疗的疗效及评估哮喘控制水平.方法:(1)采用回顾性研究和临床随访的方法,选取在我院哮喘门诊就诊的哮喘患儿200例,按照哮喘控制简易方案(easyasthma management)进行病情严重程度分级,采取半随机自愿的形式(愿意接受激素治疗与拒绝激素治疗)分为两组,治疗组100例,根据病情程度给予FP治疗,非治疗组100例给予相关的对症治疗,疗程4周.治疗组在治疗2、4周后进行重新评估,比较治疗组在治疗前后日间及夜间症状评分改善情况,且以非治疗组同期观察哮喘控制情况作对比.(2)对200例哮喘患儿中≥4岁的98例检测峰流速(PEFR)值,对比治疗组在治疗前后此值变化情况及两组间该值对比情况.结果:(1)治疗组与非治疗组在年龄、性别、治疗前病情严重程度、日间及夜间症状评分均差异无统计学意义(P＞0.05)；治疗组在吸入FP治疗2、4周后各项症状评分均明显改善(P＜0.001)；治疗组与非治疗组2、4周后日间、夜间症状评分比较差异有统计学意义(P ＜0.001).(2)治疗组在吸入FP 4周后PEFR值比治疗前明显改善(P＜0.001),与非治疗组比较差异亦有统计学意义(P ＜0.001).结论:吸入FP疗效明显,是目前较佳的支气管哮喘的治疗方法.

Effect observation on the therapy of inhaling fluticasone propionate for asthma children

Objective: To observe the effect of inhaling fluticasone propionate(FP) for asthma children,and to evaluate asthma control level.Methods:(1) With the method of retrospective study and clinical follow-up,200 cases of asthma children were selected who ever came to asthma outpatient clinic in our hospital.Disease severity was classified according to easy asthma management.On a semi-random voluntary base,these 200 children were divided into two groups on average:treatment group and non-treatment group.FP therapy was given to treatment group,and non-FP therapy to another group,the treatment period was 4 weeks,same for both groups.In order to compare the symptom improvement in the daytime and nighttime in treatment group and to contrast the effect between the two groups,re-evaluation was made two and four weeks later.(2) Ninety-eight children,above 4 years old,whose peak expiratory flow rate(PEFR) was examined for contrasting the changes in the treatment group and between the two groups.Results:(1) there were no significant differences in age,sex,disease severity,daytime and nighttime symptom grading between the two groups before the treatment(P>0.05),after the FP treatment,the symptom grading made significant improvement two and four weeks later(P<0.001),but it made a significant difference between the two groups(P<0.001).(2) The PEFR of the treatment group improved significantly after two and four weeks(P<0.001),but the two groups had a significant difference on it(P<0.001).Conclusion: Inhaled corticosteroids therapy takes a significant effect,and it can be regarded as an excellent therapy for asthma.