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| 细胞凋亡及其在牙周炎发病中的分子机制 | |
| 引用本文： | 陈铁楼,吴织芬. 细胞凋亡及其在牙周炎发病中的分子机制[J]. 同济大学学报(医学版), 2011, 32(4): 116-119. DOI: 10.3969/j.issn1008-0392.2011.04.028 |
| 作者姓名： | 陈铁楼 吴织芬 |
| 作者单位： | 解放军第411医院口腔牙周科,上海,200081 |
| 基金项目： | 南京军区“十一五”课题，上海市虹口区重点课题 |
| 摘 要： | 细胞凋亡（apoptosis）在牙周炎发病中起重要作用。细胞凋亡的调控基因主要有p53、Bcl-2、c-mys,而Fas和FasL相互作用与细胞凋亡发生关系密切。牙周炎细胞凋亡主要有两个途径,其一是通过线粒体诱导的内途径,另一是通过死亡受体信号传导通道发挥作用的外途径。本文探讨细胞凋亡在牙周炎的基因调控机制,为牙周炎的防治提供依据。 |
| 关 键 词： | 细胞凋亡 分子机制 牙周炎 线粒体 |
Molecular mechanism of apoptosis in pathogenesis of periodontitis |
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| CHEN Tie-lou and WU Zhi-fen. Molecular mechanism of apoptosis in pathogenesis of periodontitis[J]. Journal of Tongji University(Medical Science), 2011, 32(4): 116-119. DOI: 10.3969/j.issn1008-0392.2011.04.028 | |
| Authors: | CHEN Tie-lou and WU Zhi-fen |
| Affiliation: | 1.Dept.of Periodontal,Oral Research Center,the PLA Navy 411 Hospital,Shanghai 200081,China; 2.College of Stomatological,Fourth Military Medical University of PLA,Xi’an 710032,China) |
| Abstract: | The article reviews the molecular mechanism of apoptosis in the pathogenesis of periodontitis and provides the foundation for research on periodontitis.This article indicates the main control genes of apoptosis are P53,Bcl-2 and c-mys.Reciprocity of Fas and Fasl is related to apoptosis.Two major pathways are involved in the process of apoptosis in periodontitis.One is the intrinsic pathway for apoptosis induced by mitochondria,known as the intrinsic pathway.The death receptor(Fas/FasL) has been involved in the second pathway,also known as the extrinsic pathway. The apoptosis is also related to lipid perioxidation.Tetracycline and vitamin C has the therapeutic effect for periodontitis by inhibiting apoptosis. |
| Keywords: | apoptosis molecular mechanism periodontitis mitochondria |
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