| Moclobemide up-regulates proliferation of hippocarnpal progenitor cells in chronically stressed mice |
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| 引用本文： | Yun-feng LI,You-zhi ZHANG,Yan-qin LIU,Heng-lin WANG,Li YUAN,Zhi-pu LUOBeijing Institute of Pharmacology and Toxicology,Beijing 100850, Department of Anesthesiology,309 Hospital of Beijing,Beijing 100091,China. Moclobemide up-regulates proliferation of hippocarnpal progenitor cells in chronically stressed mice[J]. Acta pharmacologica Sinica, 2004, 0(11) |
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| 作者姓名： | Yun-feng LI You-zhi ZHANG Yan-qin LIU Heng-lin WANG Li YUAN Zhi-pu LUOBeijing Institute of Pharmacology and Toxicology Beijing 100850 Department of Anesthesiology 309 Hospital of Beijing Beijing 100091 China |
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| 作者单位： | Yun-feng LI，You-zhi ZHANG，Yan-qin LIU，Heng-lin WANG，Li YUAN，Zhi-pu LUOBeijing Institute of Pharmacology and Toxicology，Beijing 100850; Department of Anesthesiology，309 Hospital of Beijing，Beijing 100091，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China(No30300419)Natural Science Foundation of Beijing City(No7042052). |
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| 摘 要： | ![]()
AIM: To explore the action mechanism of antidepressants. METHODS: The PC12 cell proliferation was detected by flow cytometry,. The proliferation of hippocampal progenitor cells and level of brain-derived neurotrophic factor (BDNF) were measured by immunohistochemistry. RESULTS: Treatment with N-methylaspartate (NMDA) 600μmol/L for 3 d significantly decreased the percentage of S-phase in PC12 cells, while in the presence of classical antidepressant, moclobemide (MOC) 2 and 10μmol/L, the percentage in S-phase increased. Furthermore, the proliferation of progenitor cells in hippocampal dentate gyrus (subgranular zone), as well as the level of BDNF in hippocampus significantly decreased in chronically stressed mice, while chronic administration with MOC 40 mg/kg (ip) up-regulated the progenitor cell proliferation and BDNF level in the same time course. CONLUSION: Up-regulation of the proliferation of hippocampal progenitor cells is one of the action mechanisms for MOC, which may be closely related to the e
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Moclobemide up-regulates proliferation of hippocarnpal progenitor cells in chronically stressed mice |
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| Yun-feng LI,You-zhi ZHANG,Yan-qin LIU,Heng-lin WANG,Li YUAN,Zhi-pu LUOBeijing Institute of Pharmacology and Toxicology,Beijing . Moclobemide up-regulates proliferation of hippocarnpal progenitor cells in chronically stressed mice[J]. Acta pharmacologica Sinica, 2004, 0(11) |
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| Authors: | Yun-feng LI You-zhi ZHANG Yan-qin LIU Heng-lin WANG Li YUAN Zhi-pu LUOBeijing Institute of Pharmacology Toxicology Beijing |
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| Affiliation: | Yun-feng LI,You-zhi ZHANG,Yan-qin LIU,Heng-lin WANG,Li YUAN,Zhi-pu LUOBeijing Institute of Pharmacology and Toxicology,Beijing 100850, Department of Anesthesiology,309 Hospital of Beijing,Beijing 100091,China |
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| Abstract: | ![]()
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| Keywords: | antidepressants moclobemide neurogenesis stress brain-derived neurotrophic factor N-methylaspartate |
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