| 实验性局灶性脑缺血再灌注后HSP70 mRNA的表达 |
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| 引用本文： | 谷文萍,杨期东,史伟雄,谢光洁,周艳宏. 实验性局灶性脑缺血再灌注后HSP70 mRNA的表达[J]. 卒中与神经疾病, 2001, 8(2): 74-76 |
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| 作者姓名： | 谷文萍 杨期东 史伟雄 谢光洁 周艳宏 |
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| 作者单位： | 湖南医科大学湘雅医院神经病学研究, |
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| 摘 要： | 目的：探讨脑缺血后HSP70mRNA表达变化,方法：采用沙土鼠短暂前脑缺血再灌注损伤模型。Northern blot定量检测HSP70m RNA表达,结果：沙土鼠前脑缺血6分钟再灌注后各时期HSP70 mRNA表达量增加（P＜0．05）,热休克预处理能增加沙土鼠短暂前脑缺血再灌注后各时期HSP70 mRNA表达（P＜0．05）,结论：沙土鼠前脑缺血6分钟再灌注后各时期HSP70 mRNA表达增加,热休克预处理增加HSP70mRNA表达。
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| 关 键 词： | 脑缺血 HSP70 再灌注损伤 表达 |
Expression of HSP_(70) mRNA in the gerbil after focal cerebral ischemia and reperfusion |
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| Gu Wenping,Yang Qidong,Shi Weixiong,et al.. Expression of HSP_(70) mRNA in the gerbil after focal cerebral ischemia and reperfusion[J]. Stroke and Nervous Diseases, 2001, 8(2): 74-76 |
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| Authors: | Gu Wenping Yang Qidong Shi Weixiong et al. |
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| Affiliation: | Gu Wenping,Yang Qidong,Shi Weixiong,et al. The Institute of Neurology,Xiang Ya Hospital,Hunan Medical University,Changsha 410008 |
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| Abstract: | Objective To study the expression of HSP 70 mRNA following transient forebrain ischemia in the gerbil. Methods Northern blot were used to determine the expression of the HSP 70 mRNA of the forebrain during different periods after post ischemic reperfusion in the gerbil. Results The HSP 70 mRNA expression was increased in the forebrain ischemia after 6 min ( P < 0.05 ); Heat preconditioning could increase the expression of HSP 70 mRNA ( P < 0.05 ). Conclusion There was HSP 70 mRNA induction in the forebrain after reperfusion, heat preconditioning could increase the expression of the HSP 70 mRNA. |
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| Keywords: | Cerebral ischemia HSP 70 Reperfusion injury |
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