| 自体骨髓间充质干细胞移植治疗心肌梗死的时机选择 |
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| 引用本文： | 王梦洪,付勇南,郑泽琪,彭景添,张智亮,吴友平,黄俊,路军,汪泱. 自体骨髓间充质干细胞移植治疗心肌梗死的时机选择[J]. 临床心血管病杂志, 2009, 25(4) |
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| 作者姓名： | 王梦洪 付勇南 郑泽琪 彭景添 张智亮 吴友平 黄俊 路军 汪泱 |
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| 作者单位： | 南昌大学第一附属医院心内科,南昌,330006;南昌大学泌尿外科研究所 |
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| 基金项目： | 江西省卫生厅资助项目 |
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| 摘 要： | 目的:评价不同时机骨髓间充质干细胞(BMSCs)移植治疗急性心肌梗死(AMI)的疗效.方法:44例首次急性ST段抬高型AMI患者,在急诊成功开通梗死相关冠状动脉后随机分为AMI后第1周移植组(A组,10例)、AMI后第2、第3周移植组(B组,10例)、AMI后第4至6周移植组(C组,11例)和对照组(仅行PCI术,不进行骨髓穿刺或冠状动脉内输注,13例).各组于AMI后3 d、6个月行经胸超声心动图,采用99MTc-MIBI核素的单光子放射计算机断层显像术进行心肌灌注显像.结果:与对照组相比,A组和B组左室射血分数显著提高,心肌灌注缺损指数明显下降.A组与B组间未见明显差异,而C组与对照组相比亦未见明显差异.A组、B组、C组均未出现恶性心律失常和其他严重并发症.结论:AMI急诊介入术后行BMSCs移植是安全的.AMI后前3周行BMSCs移植比较理想.
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| 关 键 词： | 心肌梗死 骨髓间充质干细胞 移植 时机 |
Optimal time for autologous bone marrow mesenchymal stem cells transfer in patients with myocardial infarction |
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| WANG Menghong,FU Yongnan,ZHENG Zeqi,PENG Jingtian,ZHANG Zhiliang,WU Youping,HUANG Jun,LU Jun,WANG Yang. Optimal time for autologous bone marrow mesenchymal stem cells transfer in patients with myocardial infarction[J]. Journal of Clinical Cardiology, 2009, 25(4) |
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| Authors: | WANG Menghong FU Yongnan ZHENG Zeqi PENG Jingtian ZHANG Zhiliang WU Youping HUANG Jun LU Jun WANG Yang |
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| Affiliation: | 1Department of Cardiology;the First Affiliate Hospital;Nanchang University;Nanchang;330006;China;2Institute of Urinary Surgery;Nanchang University |
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| Abstract: | Objective:To investigate the optimal time for autologous bone marrow mesenchymal stem cells(BMSCs) transfer in patients with myocardial infarction(MI).Method:A total of forty-four patients with ST segment elevation AMI,who underwent coronary intervention treatment in emergency room,were divided into four groups including group A(with BMSCs transplantation at 1 week post AMI),group B(2,3 week post AMI),group C(4,5,6 week post AMI),and control group(without transplantation post AMI).Echocardiogram and nuclear... |
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| Keywords: | myocardial infarction bone marrow mesenchymal stem cells cell transplantation timing |
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