| 高效液相色谱法测定茜草双酯固体分散体中茜草双酯的含量 |
| |
| 引用本文： | 陈莉,肖若蕾,张玉霖,石露.高效液相色谱法测定茜草双酯固体分散体中茜草双酯的含量[J].解放军药学学报,2009,25(2):174-176. |
| |
| 作者姓名： | 陈莉 肖若蕾 张玉霖 石露 |
| |
| 作者单位： | 咸宁学院药学院,湖北,咸宁,437100 |
| |
| 摘 要： | 目的建立茜草双酯固体分散体中茜草双酯含量的测定方法。方法采用高效液相色谱法：色谱柱为Eurospher 100-5 C18色谱柱（250mm×4．6mm，5μm）；流动相为甲醇-水（80：20）；流速：1．0mL／min；检测波长：264nm。结果茜草双酯在20．0～100．0μg·mL^-1浓度范围内线性关系良好（r=0．9998），平均回收率为100．25％，RSD为1．13％。结论本方法专属性好，灵敏、可靠，适用于茜草双酯类制剂药物浓度的检测。
|
| 关 键 词： | HPLC 茜草双酯 固体分散体 含量测定 |
Determination of Rubidate in Rubidate Solid Dispersion by HPLC |
| |
| CHEN Li,XIAO Ruo-Lei,ZHANG Yu-Lin,SHI Lu.Determination of Rubidate in Rubidate Solid Dispersion by HPLC[J].Pharmaceutical Journal of Chinese People's Liberation Army,2009,25(2):174-176. |
| |
| Authors: | CHEN Li XIAO Ruo-Lei ZHANG Yu-Lin SHI Lu |
| |
| Institution: | 1School of Pharmacy,Xianning University,Xianning 437100, Hubei China) |
| |
| Abstract: | Aim To establish a method to determine the content of rubidate in rubidate solid dispersion by HPLC. Methods HPLC was used to determine the content of rubidate in rubidate solid dispersion. The separation was performed on Eurospher C18 （250mm ×4.6mm, 5μm） column with methanol-water （80： 20） as the mobil phase. The flow rate was 1.0mL/min and the wavelength was UV 264nm. Results The linear response range from 20.0 - 100.0μg·mL^-1 （r = 0. 999 8）. The recovery rate was 100.25%, RSD = 1.13%. Conclusion The HPLC method, specific, sensitive and reliable, can be used in the detection of drug concentration. |
| |
| Keywords: | HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
