| 牛磺酸对离体大鼠肝脏线粒体钙摄取和释放的影响 |
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| 引用本文： | 陈岳祥 佟利家. 牛磺酸对离体大鼠肝脏线粒体钙摄取和释放的影响[J]. 医学争鸣, 1992, 13(4): 282-283 |
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| 作者姓名： | 陈岳祥 佟利家 |
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| 作者单位： | 唐都医院消化内科(陈岳祥，王慎传，赵国宁)，北京医科大学心肺内分泌研究室(佟利家，张灵芝，汤健)，北京医科大学心肺内分泌研究室(唐朝枢) |
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| 摘 要： | ![]()
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| 关 键 词： | 牛磺酸 肝脏 线粒体 钙摄取 |
Effect of taurine on calcium uptake and release by isolated rat liver mitochondria |
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| CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning TONG Li-Jia,ZHANG Ling-Zhi,TANG Jian and TANG Chao-Shu. Effect of taurine on calcium uptake and release by isolated rat liver mitochondria[J]. Negative, 1992, 13(4): 282-283 |
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| Authors: | CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning TONG Li-Jia ZHANG Ling-Zhi TANG Jian TANG Chao-Shu |
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| Affiliation: | CHEN Yue-Xiang WANG Shen-Chuan ZHAO Guo-Ning TONG Li-Jia,ZHANG Ling-Zhi,TANG Jian and TANG Chao-ShuDepartment of Gastroenterology,Tangdu HospitalLaboratory of Cardiopulmonary Endocrinology,Beijing Medical University |
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| Abstract: | ![]()
In order to investigate the mechanism of the protective action of taurine on hepatocytes, authors observed the effect of taurine on calcium uptake and release by isolated rat liver mitochondria. It was found that taurine significantly inhibited Ca-uptake and promoted Ca-release by mitochondria in a dose-dependant manner: 5, 10, 20 mmol/L taurine inhibited Ca-uptake by 4.46%, 12.17% and 46.65% (P<0.01) respectively; Ca-release increased by 24.25% (P<0.05), 52.58% and 52.67% (P<0.01) respectively. The result indicated this action of taurine may be an important mechanism, by which taurine exerts its cytoprotective effect. |
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| Keywords: | taurine liver mitochondria calcium uptake calcium release |
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