住院2型糖尿病患者合并尿路感染危险因素分析

目的：分析住院2型糖尿病患者尿路感染的患病情况及其临床特点，并探讨2型糖尿病患者合并尿路感染的危险因素。方法回顾性地分析香港大学深圳医院2013年10月至2014年9月内分泌与代谢科住院的2型糖尿病患者共249例，收集相应临床资料，比较尿路感染组与非感染组患者年龄、性别、体质量指数、糖尿病病程、糖化血红蛋白（HbA1c）、估算肾小球滤过率（eGFR）、肌酐、尿微量白蛋白/肌酐（ACR）、24h尿微量白蛋白定量、尿糖等指标的异同，分析2型糖尿病患者合并尿路感染的危险因素。结果住院2型糖尿病患者合并尿路感染的患病率为16.1%；年龄、性别、eGFR、ACR、24h尿微量白蛋白定量、肌酐在两组之间差异具有统计学意义（P＜0.05），女性、年龄越大、肾功能越差、尿微量白蛋白越多的患者越易合并尿路感染。而尿糖、糖尿病病程、HbA1c、体质量指数在各组之间差异无统计学意义。logistic回归分析显示性别、肌酐是尿路感染的独立危险因素。结论2型糖尿病患者合并尿路感染与性别、肌酐相关，女性、肾功能不良的患者是高危人群。

Risk factors for urinary tract infection in type 2 diabetes mellitus inpatients

Objective To investigate the prevalence of urinary tract infection （UTI） and its risk factors in type 2 diabetes mellitus （T2DM） inpatients. Methods A total of 249 T2DM inpatients admitted in our hospital from October 2013 to September 2014 were recruited in this study and retrospectively analyzed. Their clinical data, such as age, gender, body mass index （BMI）, duration of diabetes, glycosylated hemoglobin A1c （HbA1c）, estimated glomerular filtration rate （eGFR）, serum creatinine, urine microalbumin/creatinine, 24h urine albumin, and urine glucose were collected and compared between those with UTI and without. Results The prevalence of UTI in this cohort of T2DM inpatients was 16.1%. Significant difference was found in the age, gender, eGFR, creatinine, albumin/creatinine ratio （ACR）, and 24h urine albumin between the 2 groups （P〈0.05）. Females, older, worse eGFR, higher ACR and 24h ACR patients were more prone to UTI. There was no significant difference in urine glucose, duration of diabetes, HbA1c and BMI. Logistic regression analysis indicated that gender and creatinine were independent risk factors for UTI. Conclusion T2DM inpatients with UTI are associated with gender and creatinine. Women and higher creatinine are independent risk factors for T2DM inpatients.