Effect of Fructose-1,6-bisphosphate on the Nephrotoxicity Induced by Cisplatin in Rats |
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Authors: | Alan Arrieira Azambuja Adroaldo Lunardelli Fernanda Bordignon Nunes Patrick Barcelos Gaspareto Márcio Vinícius Fagundes Donadio Carlos Eduardo Poli de Figueiredo Jarbas Rodrigues de Oliveira |
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Institution: | 1.Hospital S?o Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (HSL PUCRS),Porto Alegre,Brasil;2.Laboratório de Pesquisa em Biofísica Celular e Inflama??o, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS),Porto Alegre,Brasil;3.Hospital Universitário da Universidade Federal de Santa Catarina (HU UFSC),Florianópolis,Brasil;4.Faculdade de Enfermagem, Nutri??o e Fisioterapia,Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS),Porto Alegre,Brasil |
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Abstract: | Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but its clinical use is frequently limited
by nephrotoxicity. The study presented here attempted to evaluate the effect of fructose-1,6-bisphosphate in the cisplatin-induced
nephrotoxicity in rats. The drugs were administered intraperitoneally as a single dose: sodium chloride 0.9%, cisplatin (6 mg/kg),
fructose-1,6-bisphosphate (500 mg/kg), and cisplatin plus fructose-1,6-bisphosphate (6 and 500 mg/kg, respectively). The use
of cisplatin resulted in significant elevation of serum creatinine and urea. The group that received cisplatin plus fructose-1,6-bisphosphate
presented a significantly lower level of creatinine and urea compared to the cisplatin group. Acute tubular necrosis was demonstrated
in the animals that received cisplatin and a less severe one in the cisplatin plus fructose-1,6-bisphosphate group. Fructose-1,6-bisphosphate
has a protective effect over renal function and renal parenchyma in a rat experimental model of cisplatin-induced nephrotoxicity.
The anti-inflammatory effect of fructose-1,6-bisphosphate confirms its protective effect in cases of cellular injury. |
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