恶性骨肿瘤切除后用于骨缺损修复的生物材料的研究进展

恶性骨肿瘤的治疗经过几十年的发展,生存率已较过去有了显著的提升.但是仍有不少问题困扰骨科医师.骨缺损的修复便是瘤体切除后的一个难题,包括同种异体骨在内的一些材料使得骨缺损的修复得到部分解决,但这些材料仍有不足之处.以往的材料主要针对单纯的骨缺损修复,近年来学者们对多功能的生物材料包括羟基磷灰石、壳聚糖、磷酸钙、聚乳酸-...

Development of biomaterials for bone defect repair after malignant bone tumor resection

Compared with the past decades, the survival rate of malignant bone tumors has improved significantly. But there are still thorny problems that plague orthopedic surgeons. The repair of bone defect is one of the complex problems after tumor resection. Some materials, including allogeneic bone, have solved the repair of bone defects, but these materials still have shortcomings. Previous materials have only the function of repairing defects.In recent years, scholars have explored multifunctional biological materials, including hydroxyapatite, chitosan calcium phosphate, polylactic acid-hydroxyacetic acid,and so on. This article reviews the new progress of both repairing bone defect and inhibiting tumor recurrence.