无创呼吸机治疗慢性阻塞性肺疾病合并严重Ⅱ型呼吸衰竭的临床研究

目的:探讨鼻(面)罩无创正压通气(NIPPV)在慢性阻塞性肺疾病(COPD)合并严重Ⅱ型呼吸衰竭的治疗作用。方法:回顾性研究35例伴严重Ⅱ型呼吸衰竭(PaCO2>80mmHg)的COPD急性发作期患者,在常规治疗基础上给予NIPPV治疗,并监测血气分析、临床征象等情况。结果:NIPPV 3 h迅速改善了患者的血气(PH、PaO2、PaCO2、SaO2)(P<0.05),通气24 h至治疗72 h可获进一步改善(P<0.01)。治疗成功率达88.6%(31/35)。结论:N IPPV是治疗COPD合并严重Ⅱ型呼衰竭的有效手段。

Clinical Study of Noninvasive Positive Pressure Ventilation in Severe Respiratory Failure of Chronic Obstructive Pulmonary Disease

Objective To investigate the clinic effect of the facemask noninvasive positive pressure ventilation(NIPPV) in acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods 35cases of severe respiratory failure due to COPD(PaCO2 > 80 mm Hg) were prospectively investigated,Blood gas,clinic signs were monitored before,during and after continous NIPPV.Results Bloodgases(PH,PaO2,PaCO2,SaO2)were improved rapidly 3 h after treatment(P<0.05),and further improved 24 h,72 h after treament(P<0.01),clinical effective rate was 88.6%(31/35 patients).Conclusions NIPPV is an effective therapy in severe respiratory failure due to COPD.