| 组织型纤溶酶原激活物及其抑制剂与动脉粥样硬化的关系 |
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| 引用本文： | 吴延华,曹勇军,刘春风. 组织型纤溶酶原激活物及其抑制剂与动脉粥样硬化的关系[J]. 国际脑血管病杂志, 2007, 15(7): 534-537 |
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| 作者姓名： | 吴延华 曹勇军 刘春风 |
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| 作者单位： | 215004,苏州大学附属第二医院神经内科;215004,苏州大学附属第二医院神经内科;215004,苏州大学附属第二医院神经内科 |
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| 摘 要： | 组织型纤溶酶原激活物（tPA）和纤溶酶原激活物抑制剂（PAI）是纤溶系统外激活途径的重要活性物质，绝大多数由小血管内皮细胞合成。内皮细胞损伤和功能紊乱是动脉粥样硬化形成的重要始动环节。文章综述了内皮细胞产生的tPA和PAI与动脉粥样硬化和缺血性脑血管病之间的关系。
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| 关 键 词： | 组织型纤溶酶原激活物 纤溶酶原激活物抑制剂 动脉粥样硬化 缺血性脑血管病 内皮细胞 |
| 收稿时间： | 2006-10-10 |
| 修稿时间： | 2007-01-12 |
Tissue Plasminogen Activator and Its Plasminogen Activator Inhibitor and Atherosclerosis |
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| Yan-Hua Wu,Yong-Jun Cao,Chun-Feng Liu. Tissue Plasminogen Activator and Its Plasminogen Activator Inhibitor and Atherosclerosis[J]. International Journal of Cerebrovascular Diseases, 2007, 15(7): 534-537 |
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| Authors: | Yan-Hua Wu Yong-Jun Cao Chun-Feng Liu |
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| Affiliation: | Deartment of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China |
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| Abstract: | Tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) are the important active materials of activation pathway outside fibrinolytic system, and the majority of them are synthesized by endothelial cells in small vessels. The endothelial cell injury and dysfunction are the important initial links in the formation of atherosclerosis. This article reviews the relationship between tPA/PAI derived from endothelial cells and atherosclerosis/ischemic cerebrovascular disease. |
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| Keywords: | tissue plasminogen activator plasminogen activator inhibitor atherosclerosis ischemic cerebrovascular disease endothelial cell |
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