| HPLC法测定盐酸帕唑帕尼片含量和有关物质 |
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| 引用本文： | 赵玲,赵春才,杨博,刘艳艳,施琳.HPLC法测定盐酸帕唑帕尼片含量和有关物质[J].中国药房,2012(33):3138-3139. |
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| 作者姓名： | 赵玲 赵春才 杨博 刘艳艳 施琳 |
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| 作者单位： | [1]武汉工业学院生物与制药工程学院,武汉430023 [2]南京科瑞翔医药科技有限公司,南京210019 [3]南京安格医药化工有限公司,南京210009 |
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| 摘 要： | 目的:建立测定盐酸帕唑帕尼片中主药和有关物质含量的方法。方法:采用高效液相色谱法。色谱柱为KromasilC18,流动相为乙腈-0.02mol·L-1醋酸铵缓冲液(35:65),流速为1.0mL·min-1,检测波长为268nm,柱温为25℃,进样量为20μL。结果:盐酸帕唑帕尼检测浓度线性范围为40.18～361.6μg·mL-1(r=0.9999),检测限为2ng,平均回收率为99.60%,RSD=0.53%(n=9)。结论:该方法操作简便、快捷、准确、可靠,可用于盐酸帕唑帕尼片的质量控制。
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| 关 键 词： | 盐酸帕唑帕尼片 有关物质 含量测定 高效液相色谱法 |
Content Determination of Main Component and Related Substances in Pazopanib Hydrochloride Tablets by HPLC |
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| ZHAO LingSchool of Biology and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan,China ZHAO Chun-cai,LIU Yan-yan,SHI Lin.Content Determination of Main Component and Related Substances in Pazopanib Hydrochloride Tablets by HPLC[J].China Pharmacy,2012(33):3138-3139. |
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| Authors: | ZHAO LingSchool of Biology and Pharmaceutical Engineering Wuhan Polytechnic University Wuhan China ZHAO Chun-cai LIU Yan-yan SHI Lin |
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| Institution: | (Nanjing Keruixiang Pharmaceutical Co.,Ltd.,Nanjing 210019,China) YANG Bo(Nanjing Ange Pharmaceutical Co.,Ltd.,Nanjing 210009,China) |
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| Abstract: | OBJECTIVE：To develop a method for the content determination of main component and related substances in Pazopanib hydrochloride tablets.METHODS：HPLC method was adopted.The determination was performed on Kromasil C18 column with mobile phase composed of acetonitrile-0.02 mol·L-1 ammonium acetate solution（35：65） at the flow rate of 1.0 mL·min-1.The detection wavelength was set at 268 nm at 25 ℃.The injection size was 20 μL.RESULTS：The linear range of pazopanib hydrochloride was 40.18～361.6 μg·mL-1（r=0.999 9）.The detection limit was 2 ng and average recovery rate was 99.60%（RSD=0.53%,n=9）.CONCLUSION：The method is simple,rapid,accurate and reliable,and it is applicable for the quality control of Pazopanib hydrochloride tablets. |
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| Keywords: | Pazopanib hydrochloride tablets Related substance Content determination HPLC |
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