盐酸羟考酮缓释片与硫酸吗啡缓释片直肠给药控制重度癌性疼痛的疗效比较

目的:比较盐酸羟考酮缓释片与硫酸吗啡缓释片经直肠给药治疗重度癌性疼痛的疗效和不良反应。方法:将102例伴有中、重度疼痛的癌症患者随机分为A组(50例)与B组(52例),分别经直肠给予盐酸羟考酮缓释片和硫酸吗啡缓释片,比较2组药物起效时间、癌痛类型和药品不良反应的差异。结果:A组患者治疗1、3h时的疼痛与B组同期比较,差异有统计学意义(P<0.05),2组内脏痛和躯体痛比较差异分别有统计学意义(P<0.05),2组的不良反应如恶心、呕吐、便秘比较分别有显著性差异(P<0.05),A组均优于B组。结论:盐酸羟考酮缓释片经直肠给药控制重度癌性疼痛,安全、有效、简便。

Comparative of Therapeutic Efficacy of Oxycodone Hydrochloride Sustained-release Tablets vs. Morphine Sulfate Sustained-release Tablets for Severe Cancer Pain Control with Rectal Administration

OBJECTIVE： To compare the efficacy and adverse drug reactions of oxycodone hydrochloride sustained-release tab- lets （Oxycontin, Oxycodone hydrochloride prolonged-release tablets） and Morphine sulfate sustained-release tablets （MS Contin, Morphine sulfate） with rectal administration in the treatment of severe cancer pain. METHODS： Clinical information of 102 cases of moderate to severe cancer pain were analyzed, and they were divided into 2 groups. 50 cases were given oxycodone hydrochlo- ride sustained-release tablets with rectal administration group A and 52 cases were given morphine sulfate sustained-release tablets group B. The differences of onset time, the type of cancer pain and side effects were compared between 2 groups. RESULTS： There was statistical significance in the difference of cancer pain between 2 groups, after 1 h and 3 h treatment （P〈0.05）, there were statistical significance in the differences of visceral pain and somatic pain between 2 groups （P〈0.05） ; there were significant differences in adverse drug reactions between 2 groups, such as nausea, vomiting, constipation （P〈0.05）, and group A was better than group B. CONCLUSION： As for non-hospitalized patients, dying patients and not oral due to various reasons, transrectal ad- ministration of oxycodone hydrochloride sustained-release tablets is safe, effective and easy way to control cancer pain.