Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion |
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| Authors: | de Wilt J H ten Hagen T L de Boeck G van Tiel S T de Bruijn E A Eggermont A M |
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| Affiliation: | Department of Surgical Oncology, University Hospital Rotterdam Dijkzigt/Daniel den Hoed Cancer Centre, The Netherlands. |
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| Abstract: | ![]()
Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP. |
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| Keywords: | TNF melphalan tissue concentration isolated limb perfusion rats |
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