Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease |
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| Authors: | Chung-Dann Kan Jieh-Neng Wang Wei-Peng Li Shao-Hsien Lin Wei-Ling Chen Ya-Ping Hsu Chen-Sheng Yeh |
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| Affiliation: | 1. Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;2. Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;3. Department of Chemistry, National Cheng Kung University, Tainan, Taiwan;4. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan;5. Department of Engineering and Maintenance, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;6. Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan |
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| Abstract: | ![]()
Peripheral Arterial Occlusive Disease (PAOD) is an aging disease that affects the quality of life of many people by its intermittent claudication and critical limb ischemia presentations. Traditional treatment and management of PAOD are asking patients to make a life change and medication with antiplatelet, statins and cilostazol, which decrease the possibility of clot formation. Our strategy has employed a magnetic Fe3O4-PLGA polymersome to carry the cilostazol into the ischemic area by magnetic attraction following remote-control drug release through low-energy ultrasound exposure. In the animal studies, the cilostazol-loaded Fe3O4-PLGA polymersomes were injected and accumulated at ischemic leg through magnetic attraction. Then, using a clinical-use ultrasound machine the leg was irradiated to forward cilostazol release from the accumulated polymersomes. Dramatically, we found an observable result of bloody flux recovery in the leg after 7?days compared to the non-treated leg that showed no evidence of the blood recovery. |
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| Keywords: | Peripheral arterial occlusive disease Magnetic targeting Poly(lactic-co-glycolic acid) Polymersome Ultrasound |
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