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Lithium doped silica nanospheres/poly(dopamine) composite coating on polyetheretherketone to stimulate cell responses,improve bone formation and osseointegration |
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| Authors: | Jue Zhang Liang Cai Tinglan Wang Songchao Tang Quan Li Tingting Tang Shicheng Wei Jun Qian Jie Wei Jiacan Su |
| Affiliation: | 1. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China;2. Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai, China;3. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, PR China;4. Department of Oral and Maxillofacial Surgery, Laboratory of Interdisciplinary Studies, School and Hospital of Stomatology, Peking University, Beijing, China |
| Abstract: | Osseointegration is crucial for early fixation as well as long-term success of orthopedic implants. Bioactive composite containing lithium doping silica nanospheres (LSNs) and poly(dopamine) (PDA) were coated on polyetheretherketone (PK) surface (LPPK), and effects of the LSNs/PDA composite (LPC) coating on the biological properties of LPPK were assessed both in vitro and in vivo. Results showed that LPPK with improved bioactivity remarkably promoted apatite mineralization in simulated body fluid (SBF) compared with PDA coated on PK (PPK) and PK. Moreover, the LPPK remarkably stimulated rat bone marrow stromal cells (rBMSCs) responses compared with PPK and PK. Furthermore, the LPPK significantly promoted bone tissues responses in vivo compared with PPK and PK. It could be suggested that the improvements of cells and bone tissues responses were attributed to the surface characteristics of the bioactive LPC coating on LPPK. The LPPK would be a great candidate for orthopedic and dental applications. |
| Keywords: | Lithium doping silica nanospheres Poly(dopamine) Composite coating Polyetheretherketone Osseointegration Li lithium PDA poly(dopamine) LSNs lithium containing silica nanospheres LPC lithium containing silica nanospheres/poly(dopamine) composite coating PK polyetheretherketone PPK poly(dopamine) coated polyetheretherketone LPPK lithium containing silica nanospheres/poly(dopamine) composite coated polyetheretherketone rBMSCs rat bone marrow stromal cells FDA Food and Drug Administration hMSCs human mesenchymal stem cells SBF simulated body fluid ICP inductivity coupled plasma TEM transmission electron microscopy XRD X-ray diffraction FT-IR Fourier transform infrared spectrometry FE-SEM field emission scanning electron microscope |
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