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The diagnostic use of the second oscillatory potential in clinical electroretinography
Authors:Pierre Lachapelle  Julie Benoit  John M. Little  Jocelyn Faubert
Affiliation:(1) Department of Ophthalmology, McGill University - Montreal Children's Hospital, H3H 1P3 Montreal, Quebec, Canada;(2) Department of Neurology & Neurosurgery, McGill University - Montreal Children's Hospital, H3H 1P3 Montreal, Quebec, Canada;(3) Department of Psychology, Concordia University, H3G 1M8 Montreal, Quebec, Canada
Abstract:Of all the electroretinogram (ERG) components (a-wave, b-wave, and oscillatory potentials) only one oscillatory potential, OP2, was found to be significantly correlated with the absolute intensity of the flash stimulus (i.e., the intensity of the stimulus irrespective of the state of retinal adaptation). Our finding was further confirmed in single cell recordings of lateral geniculate unit activity in rabbits in which peak time of OP2 was found to correlate better with the geniculate activity. For these reasons we have identified OP2 as the ldquointensity codingrdquo oscillatory potential of the ERG. In order to investigate if this new feature could have some clinical significance, we examined photopic ERGs recorded from patients affected with various retinopathies. In most instances the peak time of OP2 paralleled that of the b-wave, that is, in the ERG with delayed b-wave the peak time of OP2 was also delayed, while in ERGs with normal b-wave peak time the peak time of OP2 was also normal. However, in some conditions (especially in cone-rod diseases) a delayed OP2 was found in ERGs with normal b-wave peak times.
Keywords:electroretinogram  human  oscillatory potentials  photopic  retinopathy
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