| 2型糖尿病合并骨折患者血清脂联素水平变化及相关因素分析 |
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| 引用本文： | 陈炼. 2型糖尿病合并骨折患者血清脂联素水平变化及相关因素分析[J]. 中国中医骨伤科杂志, 2011, 0(8): 15-17 |
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| 作者姓名： | 陈炼 |
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| 作者单位： | 株洲中医伤科医院关节外科; |
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| 摘 要： | 目的：探讨2型糖尿病（T2DM）合并骨折患者血清脂联素（adiponectin）水平的变化、骨密度及相关指标的关系。方法：采用酶联免疫法测定了T2DM合并骨折患者和单纯骨折患者及正常人血清adiponectin水平,采用美国NORLAND双能X线BMD仪测定L2～L4腰椎骨密度（BMD）,分析了血清adiponectin水平BMD及相关指标等的关系。结果：T2DM合并骨折患者血清adiponectin水平明显低于单纯骨折和正常对照（P〈0.05）。单纯骨折血清adiponectin水平明显低于正常对照（P〈0.05）。T2DM合并骨折患者血清adiponectin水平与高密度脂蛋白胆固醇（HDL-C）、BMD和护骨素（OPG）呈正相关,与体重指数（BMI）、腰臀比（WHR）和HOMA-胰岛素抵抗指数（HOMA-IR）呈负相关（P〈0.05）。ad-iponectin和OPG是影响T2DM合并骨折组BMD的独立相关因素。结论：血清adiponectin水平与糖脂代谢及骨代谢有关,并可能在T2DM合并骨折患者发生和发展中具有一定的作用。
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| 关 键 词： | 脂联素 糖尿病,2型 骨折 |
Changes of Serum Adiponectin Level and Related Factors in Patients with Type 2 Diabetes Complicated with Fracture |
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| CHEN Lian Dopartment of Joint Surgery,Zhuzhou Chinese Traumatology Hospital,Zhuzhou ,China. Changes of Serum Adiponectin Level and Related Factors in Patients with Type 2 Diabetes Complicated with Fracture[J]. Chinese Journal of Traditional Medical Traumatology & Orthopeics, 2011, 0(8): 15-17 |
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| Authors: | CHEN Lian Dopartment of Joint Surgery Zhuzhou Chinese Traumatology Hospital Zhuzhou China |
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| Affiliation: | CHEN Lian1 1Dopartment of Joint Surgery,Zhuzhou Chinese Traumatology Hospital,Zhuzhou 412000,China |
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| Abstract: | Objective:To investigate the changes of serum adiponectin level and the relationship between serum adiponectin level and BMD,in patients with T2DM complicated with fracture.Methods:Serum adiponectin levels were measured separately by an ELISA in patients with type 2 diabetes complicated with fracture,simple fracture and normal controls.BMD of Lumbar vertebrae(L2~L4) was measured by dual energy X-ray absorptiometry(DEXA).The relationship between serum adiponectin and BMD were also analyzed.Results:Serum adip... |
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| Keywords: | Adiponectin Type 2 diabetes mellitus Fracture |
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