| 维生素D受体基因的多态性与检测方法 |
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| 引用本文： | 游春华,熊筱娟,王清华,陈万生,高守红.维生素D受体基因的多态性与检测方法[J].药学实践杂志,2014,32(5):329-331,392. |
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| 作者姓名： | 游春华 熊筱娟 王清华 陈万生 高守红 |
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| 作者单位： | 第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西 宜春 336000,宜春学院化学与生物工程学院, 江西 宜春 336000,第二军医大学附属长征医院药学部, 上海 200003;宜春学院化学与生物工程学院, 江西 宜春 336000,第二军医大学附属长征医院药学部, 上海 200003,第二军医大学附属长征医院药学部, 上海 200003 |
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| 摘 要： | 近年研究发现,维生素D缺乏除与骨软化相关外,还与高血压、糖尿病、代谢综合征等多种疾病相关。维生素D在体内经肝脏和肾脏两次羟基化后作用于其受体而发挥生理作用。笔者通过查阅国内外相关文献,介绍维生素D与疾病的关系及维生素D受体基因多态性研究现状,阐述检测维生素D常用方法的优缺点,提出检测维生素D的最佳方法及其受体基因多态性检测的重要性,从而指导临床医生合理用药。
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| 关 键 词： | 维生素D 基因多态性 维生素D受体 合理用药 |
| 收稿时间： | 2013/12/20 0:00:00 |
| 修稿时间： | 2014/4/26 0:00:00 |
Study on receptor gene polymorphism and detection method of vitamin D |
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| YOU Chunhu,XIONG Xiaojuan,WANG Qinghu,CHEN Wansheng and GAO Shouhong.Study on receptor gene polymorphism and detection method of vitamin D[J].The Journal of Pharmaceutical Practice,2014,32(5):329-331,392. |
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| Authors: | YOU Chunhu XIONG Xiaojuan WANG Qinghu CHEN Wansheng and GAO Shouhong |
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| Institution: | Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Yichun University, College of Chemistry and Bio-engineering, Yichun 336000, China,Yichun University, College of Chemistry and Bio-engineering, Yichun 336000, China,Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Yichun University, College of Chemistry and Bio-engineering, Yichun 336000, China,Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China and Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200433, China |
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| Abstract: | In recent years,many studies have found that vitamin D insufficiency is associated with osteomalacia,hypertension,diabetes,metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time,and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1,25-dihydroxy vitamin D,which binds to the intracellular vitamin D receptor and exerts its effects. This paper reviewed the relationship between vitamin D and disease,present research situation of gene polymorphism of vitamin D receptor,and the advantages and limitations of several methods of vitamin D detection,and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally. |
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| Keywords: | vitamin D gene polymorphism vitamin D receptor rational drug use |
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