Prognostic significance of glucose-related protein 94 in colorectal cancer |
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| Affiliation: | 1. Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan;2. Department of Dermatology, National Defense Medical College, Tokorozawa, Japan;3. Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan;4. Department of Regulation Biochemistry, Kitasato University, School of Allied Health Science, Kanagawa, Japan;5. Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Tokyo, Japan;6. Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan |
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| Abstract: | AimsThe expression of glucose-related protein 94 (GRP94), a member of the heat shock protein 90 family, was correlated with a variety of clinicopathological factors and patient survival in a large colorectal cancer (CRC) cohort. We aimed to elucidate the role of GRP94 in the prognosis of CRC patients.MethodsTissue microarray blocks were generated from 709 CRC samples and immunohistochemically stained for GRP94.ResultsOf the 709 tumours, 164 (23.1%) and 545 (76.9%) were classified in the low and high expression groups, respectively. GRP94 expression was high in CRC cases with larger tumours (p = 0.005) and advanced pT stage (p = 0.021). GRP94 expression was higher in females than males (p = 0.024). In univariate and multivariate survival analyses, high GRP94 expression was unexpectedly associated with better overall survival in CRC patients younger than 65 years of age (p = 0.001)ConclusionOur conflicting results indicate that GRP94 has the ability to switch between oncogenic and tumour-suppressive roles depending on the conditions and microenvironment of the tumour cells. Furthermore, GRP94 could be a candidate biomarker to predict better prognosis in CRC patients. |
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| Keywords: | Colorectal cancer GRP94 Immunohistochemistry Prognosis |
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