FoxO3a immunoreactivity is markedly decreased in the dentate gyrus, not the hippocampus proper, of the aged gerbil |
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| Authors: | Park Joon Ha Lee Choong Hyun Yoo Ki-Yeon Choi Jung Hoon Hwang In Koo Lee Jae-Yong Kang Il-Jun Won Moo-Ho |
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| Affiliation: | aDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 200–701, South Korea;bLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul 151–742, South Korea;cDepartment of Oral Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung 210–702, South Korea;dDepartment of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 200–701, South Korea;eDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151–742, South Korea;fDepartment of Biochemistry, College of Medicine, Hallym University, Chuncheon 200–702, South Korea;gDepartment of Food Science and Nutrition, Hallym University, Chuncheon 200–702, South Korea |
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| Abstract: | ![]()
Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyramidal cells of the hippocampus proper, and granule cells of the dentate gyrus. FoxO3a immunoreactivity in the pyramidal cells of the hippocampus proper was not changed until PM 24. However, in the dentate granule cells, FoxO3a immunoreactivity was much decreased in the dorsal blade, not the ventral blade, of the granule cell layer in the PM 6 and 12 groups compared to the PM 3 group. At PM 24, FoxO3a immunoreactivity in the granule cells was hardly detected. Western blot analysis showed that FoxO3a level was significantly decreased in the PM 24 group. These results indicate that FoxO3a immunoreactivity and levels are markedly decreased in the dentate gyrus of the aged gerbil hippocampus. |
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| Keywords: | Forkhead box O proteins Aging Senescence Pyramidal cells Granule cells |
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