Adult Celiac Disease Associated with HLA-DRw3 and -DRw7 |
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| Authors: | H. Betuel L. Gebuhrer L. Descos H. Percebois Y. Minaire J. Bertrand |
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| Affiliation: | Histocompatibility Laboratory, Blood Transfusion Centre, Lyon;Department of Hepato-Gastro-Enterology, Hospital Edouard Herriot, Lyon, France |
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| Abstract: | ![]()
Celiac disease (CD), which occurs in Europe with varying frequency, is known to be associated with HLA-B8 and even more strongly with HLA-Dw3 because of the high linkage disequilibrium between these two antigens. After typing for HLA-A, ∼B and -DR antigens in adult patients with CD, we can confirm the high prevalence of B8 (72.7%) and of DRw3 (63.7%). However we find that DRw7 is also significantly increased (54.5%); DRw3 and DRw7, taken together, represent 86% of our 22 patients. |
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