| 局灶性脑缺血再灌注大鼠IL—1Ra mRNA的表达 |
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| 引用本文： | 许贞峰,吴根诚,曹小定.局灶性脑缺血再灌注大鼠IL—1Ra mRNA的表达[J].青岛大学医学院学报,2001,37(4):271-273. |
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| 作者姓名： | 许贞峰 吴根诚 曹小定 |
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| 作者单位： | 1. 青岛大学医学院脑血管病研究所
2. 复旦大学 |
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| 基金项目： | 国家自然基金重点资助项目(39730510) |
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| 摘 要： | 目的 观察脑缺血再灌注后白细胞介素 1受体拮抗剂 (IL 1Ra)mRNA的表达。②方法 采用线栓法制备SD大鼠局灶性大脑中动脉阻塞 (MCAO)动物模型 ,应用RT PCR方法观察脑缺血再灌注对大鼠IL 1RamRNA表达的影响。③结果 MCAO模型大鼠缺血侧大脑皮质再灌注后 12 ,2 4h的IL 1RamRNA表达与正常对照组比较明显增加 (F =39.84,q=9.0 3,15 .91,P <0 .0 0 1) ;缺血侧纹状体缺血再灌注后 12h的IL 1RamRNA表达与正常对照组比较明显增加 (F =7.37,q=6 .5 4,P <0 .0 0 1)。④结论 脑缺血后内源性IL 1RamRNA表达增加 ,可能是机体对缺血性损伤的自我保护机制。
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| 关 键 词： | 脑缺血 再灌注损伤 白细胞介素－1受体 拮抗剂 抑制剂 mRNA IL－1Ra |
| 文章编号： | 1001-4047(2001)04-0271-03 |
| 修稿时间： | 2001年4月19日 |
THE EXPRESSION OF IL-1Ra mRNA AFTER FOCAL CEREBRAL ARTERY OCCLUSION IN RATS |
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| XU Zhenfeng,WU Gencheng,CAO Xiaoding \ Cerebrovascular Disease Institute of Qingdao University Medical College,Qingdao \.THE EXPRESSION OF IL-1Ra mRNA AFTER FOCAL CEREBRAL ARTERY OCCLUSION IN RATS[J].Acta Academiae Medicinae Qingdao Universitatis,2001,37(4):271-273. |
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| Authors: | XU Zhenfeng WU Gencheng CAO Xiaoding \ Cerebrovascular Disease Institute of Qingdao University Medical College Qingdao \ |
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| Institution: | XU Zhenfeng,WU Gencheng,CAO Xiaoding \ Cerebrovascular Disease Institute of Qingdao University Medical College,Qingdao 266003 \, |
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| Abstract: | Objective\ To investigate the expression of interleukin 1 receptor antagonist (IL 1Ra) mRNA after cerebral ischemia reperfusion in rats. \ Methods\ RT PCR was used to explore IL 1Ra mRNA expression in middle cerebral artery occlusion (MCAO) rat model. \ Results\ IL 1Ra mRNA expression was rapidly induced after 12 and 24 hours of MCAO reperfusion as compared with the normal control group( F=39.84, q=9.03, 15.91,P <0.001). The expression of IL 1Ra mRNA after 12 hours of reperfusion in ischemic cortex increased markedly compared with the normal control( F=7.34, q=6.54, P <0.001).\ Conclusion\ Our results indicated that IL 1Ra mRNA may play an important role in the protection of ischemic brain damage. |
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| Keywords: | cerebral ischemia reperfusuin interleukin 1 receptor antagonists and inhibitors |
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