Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase,pegcrisantaspase: A report from the Children's Oncology Group |
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| Authors: | Rachel E. Rau ZoAnn Dreyer Mi Rim Choi Wei Liang Roman Skowronski Krishna P. Allamneni Meenakshi Devidas Elizabeth A. Raetz Peter C. Adamson Susan M. Blaney Mignon L. Loh Stephen P. Hunger |
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| Affiliation: | 1. Division of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas;2. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas;3. Jazz Pharmaceuticals, Palo Alto, California;4. Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, Florida;5. Department of Pediatrics, University of Utah, Salt Lake City, Utah;6. Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;7. Department of Pediatrics, University of California School of Medicine, San Francisco, California |
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| Abstract: | 1 Background Erwinia asparaginase is a Food and Drug Administration approved agent for the treatment of acute lymphoblastic leukemia (ALL) for patients who develop hypersensitivity to Escherichia coli derived asparaginases. Erwinia asparaginase is efficacious, but has a short half‐life, requiring six doses to replace one dose of the most commonly used first‐line asparaginase, pegaspargase, a polyethylene glycol (PEG) conjugated E. coli asparaginase. Pegcristantaspase, a recombinant PEGylated Erwinia asparaginase with improved pharmacokinetics, was developed for patients with hypersensitivity to pegaspargase. Here, we report a series of patients treated on a pediatric phase 2 trial of pegcrisantaspase. 2 Procedure Pediatric patients with ALL or lymphoblastic lymphoma and hypersensitivity to pegaspargase enrolled on Children's Oncology Group trial AALL1421 (Jazz 13‐011) and received intravenous pegcrisantaspase. Serum asparaginase activity (SAA) was monitored before and after dosing; immunogenicity assays were performed for antiasparaginase and anti‐PEG antibodies and complement activation was evaluated. 3 Results Three of the four treated patients experienced hypersensitivity to pegcrisantaspase manifested as clinical hypersensitivity reactions or rapid clearance of SAA. Immunogenicity assays demonstrated the presence of anti‐PEG immunoglobulin G antibodies in all three hypersensitive patients, indicating a PEG‐mediated immune response. 4 Conclusions This small series of patients, nonetheless, provides data, suggesting preexisting immunogenicity against the PEG moiety of pegaspargase and poses the question as to whether PEGylation may be an effective strategy to optimize Erwinia asparaginase administration. Further study of larger cohorts is needed to determine the incidence of preexisting antibodies against PEG‐mediated hypersensitivity to pegaspargase. |
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| Keywords: | acute lymphoblastic leukemia asparaginase hypersensitivity |
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