| 达尔康对吗啡依赖大鼠戒断症状的影响 |
| |
| 引用本文： | 黄新洁,崔艳英,宁亚清,尹萍,陈磊,邱毅,潘励山.达尔康对吗啡依赖大鼠戒断症状的影响[J].中国药物依赖性杂志,2003,12(1):21-23. |
| |
| 作者姓名： | 黄新洁 崔艳英 宁亚清 尹萍 陈磊 邱毅 潘励山 |
| |
| 作者单位： | 北京大学中国药物依赖性研究所,北京,100083 |
| |
| 摘 要： | 目的 :观察中药达尔康对吗啡依赖大鼠戒断症状的抑制作用。方法 :采用剂量递增法皮下注射吗啡 14d和3 0d ,分别建立大鼠吗啡依赖模型 ,观察达尔康大、中、小 3个剂量对吗啡依赖大鼠纳洛酮催促和自然戒断的戒断症状及体重的影响。结果 :达尔康能显著减轻吗啡依赖大鼠ip纳洛酮引起的催促戒断症状 (P <0 .0 5 )和体重下降(P <0 .0 1) ,能抑制自然戒断大鼠体重下降 (P <0 .0 1和P <0 .0 5 )。结论 :达尔康对吗啡依赖大鼠戒断反应有明显的抑制作用
|
| 关 键 词： | 达尔康 吗啡依赖 戒断反应 |
| 修稿时间： | 2002年6月28日 |
EFFECT OF DAERKANG ON WITHDRAWAL RESPONSES IN MORPHINE DEPENDENT RATS |
| |
| HUANG Xinjie,CUI Yanying,NING Yaqing,YIN Ping,CHEN Lei,QIU Yi,PAN Lishan.EFFECT OF DAERKANG ON WITHDRAWAL RESPONSES IN MORPHINE DEPENDENT RATS[J].Chinese Journal of Drug Dependence,2003,12(1):21-23. |
| |
| Authors: | HUANG Xinjie CUI Yanying NING Yaqing YIN Ping CHEN Lei QIU Yi PAN Lishan |
| |
| Abstract: | Objective : To observe the inhibit effect of Daerkang, a traditional Chinese medicine on withdrawal responses of morphine dependent rats. Methods : Models of morphine dependent rats were set up by morphine(sc) with gradually increasing doses for 14 days and 30 days, respectively. The effects of high, middle and low doses of Daerkang on withdrawal responses and weight loss were observed on naloxone precipitated and natural withdrawal symptoms. Results : Daerkang reduced the withdrawal symptoms and inhibited the weight loss induced by naloxone(ip) in morphine dependent rats, and weight loss in natural withdrawal rats. Conclusion : Daerkang has significant effect on the control of withdrawal responses of morphine dependent rats. |
| |
| Keywords: | Daerkang morphine dependent rats withdrawal responses |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
