| 中药对肾小球硬化模型TGF-β1表达的影响 |
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| 引用本文： | 于克波,王太华,张新焕.中药对肾小球硬化模型TGF-β1表达的影响[J].泰山医学院学报,2008,29(7):484-488. |
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| 作者姓名： | 于克波 王太华 张新焕 |
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| 作者单位： | 泰山医学院附属医院肾内科,山东,泰安,271000 |
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| 摘 要： | 目的观察活血化瘀等中药治疗慢性肾小球硬化的机理。方法将实验动物随机分组,制备阿霉素肾小球硬化动物模型,应用免疫组化检测各组动物的TGF-β1的表达水平并观察血BUN、CR的水平。结果金匮肾气汤等均能显著减少TGF-β1在肾小管间质的表达（P〈0.05）。结论金匮肾气汤等可能是通过减少TGF-β1表达而延缓肾小球硬化。
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| 关 键 词： | 阿霉素肾病 肾小球硬化 中药 TGF-β1 |
Effects of traditional Chinese herbal medicine on TGF-β1 expression of glomerulosclerosis |
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| YU Ke-bo,WANG Tai-hua,ZHANG Xin-huan.Effects of traditional Chinese herbal medicine on TGF-β1 expression of glomerulosclerosis[J].Journal of Taishan Medical College,2008,29(7):484-488. |
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| Authors: | YU Ke-bo WANG Tai-hua ZHANG Xin-huan |
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| Institution: | ( Affiliated Hospital of Taishan Medical College, Taian 271000, China, ) |
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| Abstract: | Objective： To explore the mechanism of traditional chinese herbs in treating glomerulosclerosis. Methods： 120 male Sprague-Dawley rats were divided into groups at rawdom and the model of Adriamycin-induced nephropathy and glomerulosclerosis was established to investigate the expi＇ession of transformy growth factor-β1 （ TGF-β4 ） protein. Results ： Jinkuishenqitang soup reduced the expresstion of TGF-β1 in rats（P 〈 0.05）. Conclusion： Jinkuishenqitang soup and other traditional Chinese herbal medicine can reduce the expresstion of TGF-β1 and hinder the development of glomerulosclersis. |
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| Keywords: | Adriamycin glomerulosclerosis traditional Chinese herb TGF-β1 |
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